STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppdKPyruvate,phosphate dikinase; PMID: 2176881 best DB hits: BLAST: pir:F72397; pyruvate,orthophosphate dikinase (EC 2.7.9.1) -; E=0.0 swissprot:P22983; PODK_CLOSY PYRUVATE,PHOSPHATE DIKINASE; E=0.0 pdb:1DIK; Pyruvate Phosphate Dikinase; E=0.0 COG: TM0272; COG0574 Phosphoenolpyruvate synthase; E=0.0 PA3562_3; COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI; E=2e-27 MTH1118; COG0574 Phosphoenolpyruvate synthase; E=1e-22 PFAM: PF01326; Pyruvate phosphate dikinase,; E=1.1e-167 PF00391; PEP-utilizing enzyme, mobile; E=4.1e-37 PF02896; PEP-utilizing enzyme, TIM bar; E=3e-141; Belongs [...] (890 aa)    
Predicted Functional Partners:
korA
2-oxoglutarate ferredoxin oxidoreductase alpha subunit; PMID: 11401501 best DB hits: BLAST: embl:CAC08296.1; (AL392148) putative oxidoreductase [Streptomyces; E=1e-165 embl:CAB60189.1; (AL132824) putative oxidoreductase alpha-subunit; E=1e-164 pir:F70864; probable oxidoreductase alpha subunit - Mycobacterium; E=1e-160 COG: Rv2455c_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=1e-106 Rv2455c_1; COG1014 Pyruvate:ferredoxin oxidoreductase and related; E=2e-46 BH2374_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=2e-40 PFAM: PF01855; Pyruvate flavodoxin/ferredo [...]
    
 0.946
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
 0.939
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 
 0.933
korB
2-oxoglutarate ferredoxin oxidoreductase beta subunit; PMID: 11401501 best DB hits: BLAST: embl:CAC08295.1; (AL392148) putative oxidoreductase [Streptomyces; E=1e-104 embl:CAB60188.1; (AL132824) putative oxidoreductase beta-subunit; E=1e-103 pir:E70864; probable oxidoreductase - Mycobacterium tuberculosis; E=2e-94 COG: Rv2454c; COG1013 Pyruvate:ferredoxin oxidoreductase and related; E=1e-95 PFAM: PF02775; Thiamine pyrophosphate enzyme,; E=0.19.
    
 0.933
RB307
NAD-dependent malic enzyme; PMID: 2644282 PMID: 36376 best DB hits: BLAST: swissprot:P16468; MAOX_BACST NAD-DEPENDENT MALIC ENZYME (NAD-ME); E=1e-141 embl:CAB72197.1; (AL138851) putative malate oxidoreductase; E=1e-135 pir:S74511; malic enzyme - Synechocystis sp. (strain PCC 6803); E=1e-118 COG: slr0721; COG0281 Malic enzyme; E=1e-119 PFAM: PF01842; ACT domain; E=7.3e-05 PF00390; Malic enzyme; E=0.034 PF01488; Shikimate / quinate 5-dehydrogen; E=0.17.
  
 
 0.930
pykA
Pyruvate kinase; PMID: 9387221 best DB hits: BLAST: ddbj:BAB06882.1; (AP001517) pyruvate kinase [Bacillus halodurans]; E=4e-82 swissprot:P80885; KPYK_BACSU PYRUVATE KINASE (PK) (VEGETATIVE; E=6e-80 swissprot:P51181; KPYK_BACLI PYRUVATE KINASE (PK) ----- pir:; E=1e-79 COG: BH3163_1; COG0469 Pyruvate kinase; E=4e-83 PFAM: PF00478; IMP dehydrogenase; Belongs to the pyruvate kinase family.
     
 0.929
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.929
AceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.918
RB6610
Hypothetical protein; Best DB hits: PFAM: PF00639; PPIC-type PPIASE domain; E=0.81.
  
  
 0.917
ldhA
PMID: 9025293 best DB hits: BLAST: pir:D83529; D-lactate dehydrogenase (fermentative) PA0927 [imported]; E=3e-95 pir:S76782; D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) -; E=1e-91 swissprot:P52643; LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH); E=1e-86 COG: PA0927; COG1052 Lactate dehydrogenase and related dehydrogenases; E=3e-96 PAB0514; COG0111 Phosphoglycerate dehydrogenase and related; E=3e-37 TP0037; COG1052 Lactate dehydrogenase and related dehydrogenases; E=5e-37 PFAM: PF00389; D-isomer specific 2-hydroxyacid; E=1.4e-24 PF02891; MIZ zinc finger; E=0.34 PF02826; D-isomer specific 2 [...]
    
 0.917
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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