STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ibeB-2Probable outer membrane lipoprotein IbeB; PMID: 99242786 best DB hits: BLAST: gb:AAD30205.1; (AF094824) IbeB [Escherichia coli]; E=3e-33 swissprot:P77211; IBEB_ECOLI PROBABLE OUTER MEMBRANE LIPOPROTEIN; E=4e-33 gb:AAG54905.1; AE005237_1 (AE005237) putative resistance protein; E=1e-32 COG: ylcB; COG1538 Outer membrane protein; E=4e-34 PFAM: PF02321; Outer membrane efflux protein; E=1.3e-09. (614 aa)    
Predicted Functional Partners:
mexA
Multidrug resistance protein MexA; PMID: 7968531 best DB hits: BLAST: gb:AAD12178.1; (AF029405) periplasmic linker protein [Pseudomonas; E=8e-20 swissprot:P37636; YHIU_ECOLI HYPOTHETICAL 41.2 KD LIPOPROTEIN IN; E=3e-19 gb:AAG58654.1; AE005576_13 (AE005576) putative membrane protein; E=4e-19 COG: yhiU; COG0845 Membrane-fusion protein; E=3e-20 PFAM: PF00364; Biotin-requiring enzyme; E=0.0015 PF00529; HlyD family secretion protein; E=3.1e-06; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
  0.966
acrB
Acriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.928
mexB
Similar to multidrug resistance protein MexB; PMID: 7968531 PMID: 10187844 PMID: 10984043 best DB hits: BLAST: pir:H83071; RND multidrug efflux transporter MexD PA4598 [imported]; E=7e-91 embl:CAC14595.1; (AJ252200) putative RND protein; E=2e-85 swissprot:P52002; MEXB_PSEAE MULTIDRUG RESISTANCE PROTEIN MEXB; E=6e-85 COG: PA4598; COG0841 Cation/multidrug efflux pump; E=7e-92 PFAM: PF00873; AcrB/AcrD/AcrF family; E=7.9e-188; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.918
RB149
Probable outer membrane channel protein; PMID: 9852029 best DB hits: BLAST: gb:AAD12177.1; (AF029405) outer membrane channel protein; E=0.001 gb:AAD30205.1; (AF094824) IbeB [Escherichia coli]; E=0.039 swissprot:Q51487; OPRM_PSEAE OUTER MEMBRANE PROTEIN OPRM PRECURSOR; E=0.049 COG: PA0427; COG1538 Outer membrane protein; E=0.005 PFAM: PF02321; Outer membrane efflux protein; E=0.0013.
     
  0.900
mexF
Best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:T43024; ceoB protein - Burkholderia cepacia ----- gb:; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
   0.871
RB146
Probable cation efflux system; PMID: 8203018 best DB hits: BLAST: pir:C70415; cation efflux system (czcB-like) - Aquifex aeolicus; E=2e-10 pir:B82357; conserved hypothetical protein VC0165 [imported] -; E=3e-10 ddbj:BAA34299.1; (AB015853) MexX [Pseudomonas aeruginosa]; E=5e-08 COG: aq_1331; COG0845 Membrane-fusion protein; E=2e-11 emrA; COG1566 Multidrug resistance efflux pump; E=0.003 PA3402; COG0845 Membrane-fusion protein; E=0.003 PFAM: PF00364; Biotin-requiring enzyme; E=0.0052 PF00529; HlyD family secretion protein; E=6.1e-07; Belongs to the membrane fusion protein (MFP) (TC 8.A.1 [...]
   
  0.848
mexE
PMID: 8196548 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=9e-33 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-31 embl:CAC14594.1; (AJ252200) putative membrane fusion protein; E=1e-21 COG: PA2493; COG0845 Membrane-fusion protein; E=9e-34 PFAM: PF00364; Biotin-requiring enzyme; E=0.31 PF00529; HlyD family secretion protein; E=5.5e-13; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.777
RB2379
Hypothetical protein.
       0.773
acrA
Acriflavine resistance protein A [Precursor]; PMID: 10984043 best DB hits: BLAST: pir:E83335; RND multidrug efflux membrane fusion protein MexE; E=1e-54 pir:T30829; hypothetical protein mexE - Pseudomonas aeruginosa; E=1e-52 pir:E83206; probable RND efflux membrane fusion protein precursor; E=2e-42 COG: PA2493; COG0845 Membrane-fusion protein; E=1e-55 PFAM: PF00364; Biotin-requiring enzyme; E=0.0006 PF00529; HlyD family secretion protein; E=4e-20; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
   0.702
RB2382
Hypothetical protein.
       0.549
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.