STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
eutEEthanolamine utilization protein EutE; PMID: 11677609 best DB hits: BLAST: swissprot:P41793; EUTE_SALTY ETHANOLAMINE UTILIZATION PROTEIN EUTE; E=5e-84 gb:AAG57564.1; AE005474_12 (AE005474) ethanolamine utilization; E=1e-83 swissprot:P77445; EUTE_ECOLI ETHANOLAMINE UTILIZATION PROTEIN EUTE; E=5e-83 COG: eutE; COG1012 NAD-dependent aldehyde dehydrogenases; E=5e-84 PFAM: PF00171; Aldehyde dehydrogenase family; E=0.21. (474 aa)    
Predicted Functional Partners:
RB10805
Putative iron alcohol dehydrogenase; PMID: 88038383 best DB hits: BLAST: swissprot:Q09669; ADHF_SCHPO PUTATIVE IRON ALCOHOL DEHYDROGENASE; E=5e-46 gb:AAD43989.1; U59485_16 (U59485) AttL [Agrobacterium tumefaciens]; E=5e-45 gb:AAG58733.1; AE005585_7 (AE005585) putative oxidoreductase; E=6e-42 COG: yiaY; COG1454 Alcohol dehydrogenase IV; E=3e-42 PFAM: PF00465; Iron-containing alcohol dehydrogenas; E=3.3e-58.
 0.966
korA
2-oxoglutarate ferredoxin oxidoreductase alpha subunit; PMID: 11401501 best DB hits: BLAST: embl:CAC08296.1; (AL392148) putative oxidoreductase [Streptomyces; E=1e-165 embl:CAB60189.1; (AL132824) putative oxidoreductase alpha-subunit; E=1e-164 pir:F70864; probable oxidoreductase alpha subunit - Mycobacterium; E=1e-160 COG: Rv2455c_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=1e-106 Rv2455c_1; COG1014 Pyruvate:ferredoxin oxidoreductase and related; E=2e-46 BH2374_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=2e-40 PFAM: PF01855; Pyruvate flavodoxin/ferredo [...]
   
 0.934
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.933
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.926
eutN
PMID: 11677609 best DB hits: BLAST: swissprot:P41792; EUTN_SALTY ETHANOLAMINE UTILIZATION PROTEIN EUTN; E=4e-09 swissprot:P77633; EUTN_ECOLI ETHANOLAMINE UTILIZATION PROTEIN EUTN; E=5e-09 gb:AAD39013.1; (AF026270) PduN [Salmonella enterica serovar; E=5e-09.
 
   
 0.921
RB10172
Aldehyde dehydrogenase; PMID: 9369242 best DB hits: BLAST: gb:AAA64636.1; (U07235) aldehyde dehydrogenase [Mus musculus]; E=1e-163 gb:AAA51693.1; (M20456) aldehyde dehydrogenase [Homo sapiens]; E=1e-163 pir:DEHUE2; aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) 2 precursor,; E=1e-162 COG: BH0539; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-156 PFAM: PF00171; Aldehyde dehydrogenase family; E=1.5e-240; Belongs to the aldehyde dehydrogenase family.
  
  
 
0.905
leuA-2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.905
leuA-3
2-isopropylmalate synthase; PMID: 6171647 best DB hits: BLAST: swissprot:O66682; LY41_AQUAE PUTATIVE LYASE AQ_356 ----- pir:; E=1e-132 pir:E75045; 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus; E=1e-130 swissprot:Q9WZ22; LY41_THEMA PUTATIVE LYASE TM0552 ----- pir:; E=1e-124 COG: aq_356; COG0119 Isopropylmalate/homocitrate/citramalate synthases; E=1e-133 PFAM: PF00682; HMGL-like; E=6.6e-09; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.905
aceF
PMID: 6345153 PMID: 6821375 PMID: 2121129 best DB hits: BLAST: pir:C82079; pyruvate dehydrogenase, E2 component, dihydrolipoamide; E=4e-55 pir:H75540; pyruvate dehydrogenase complex, dihydrolipoamide; E=4e-55 gb:AAK02978.1; (AE006128) AceF [Pasteurella multocida]; E=6e-54 COG: VC2413; COG0508 Dihydrolipoamide acyltransferases; E=3e-56 PFAM: PF00364; Biotin-requiring enzyme; E=2.1e-20 PF02817; e3 binding domain; E=8.5e-14 PF00198; 2-oxo acid dehydrogenases acylt; E=8.5e-100.
   
 0.905
accB
acetyl-CoA carboxylase (biotin carboxyl carrier subunit) accB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
    
  0.905
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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