STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB2732Heparan N-sulfatase; PMID: 11181566 best DB hits: BLAST: gb:AAG41945.1; AF304053_1 (AF304053) heparan N-sulfatase [Mus; E=9e-29 gb:AAF29467.1; (AF156255) N-sulfoglucosamine sulfohydrolase [Mus; E=2e-28 gb:AAG41946.1; AF304054_1 (AF304054) mutant heparan N-sulfatase; E=3e-28 COG: Rv0296c; COG3119 Arylsulfatase A and related enzymes; E=9e-29 TM1703; COG1368 Phosphoglycerol transferase and related proteins,; E=2e-04 yejM; COG3083 Predicted hydrolase of alkaline phosphatase; E=0.001 PFAM: PF00884; Sulfatase; E=2.2e-23. (555 aa)    
Predicted Functional Partners:
RB2728
PMID: 8552028 best DB hits: BLAST: pir:D82244; sensory box sensor histidine kinase VC1084 [imported] -; E=4e-15 ddbj:BAB05639.1; (AP001513) two-component sensor histidine kinase; E=1e-13 pir:S60595; FixL protein - Rhizobium leguminosarum ----- gb:; E=3e-13 COG: VC1084; COG0642 Sensory transduction histidine kinases; E=3e-16 PFAM: PF00672; HAMP domain; E=2.9e-10 PF00512; His Kinase A (phosphoacceptor) doma; E=3.2e-08 PF02518; Histidine kinase-, DNA gyrase B-, p; E=7.9e-33.
       0.773
RB2731
PMID: 8346225 best DB hits: BLAST: swissprot:Q06065; ATOC_ECOLI ACETOACETATE METABOLISM REGULATORY; E=5e-83 gb:AAC28085.1; (AF100457) response regulator [Myxococcus xanthus]; E=2e-81 swissprot:Q00934; PILR_PSEAE TYPE 4 FIMBRIAE EXPRESSION REGULATORY; E=4e-79 COG: atoC; COG2204 AAA superfamily ATPases with N-terminal receiver; E=4e-84 VC2137; COG1221 NtrC family transcriptional regulators, ATPase; E=5e-67 PFAM: PF00072; Response regulator receiver doma; E=4.1e-28 PF00158; Sigma-54 interaction domain; E=4.8e-131.
       0.773
acrB
Acriflavine resistance protein B; PMID: 8905231 PMID: 8407802 PMID: 7651136 best DB hits: BLAST: pir:F83335; RND multidrug efflux transporter MexF PA2494 [imported] -; E=0.0 pir:T30830; hypothetical protein mexF - Pseudomonas aeruginosa -----; E=0.0 pir:D83206; probable RND efflux transporter PA3522 [imported] -; E=0.0 COG: PA2494; COG0841 Cation/multidrug efflux pump; E=0.0 PFAM: PF00873; AcrB/AcrD/AcrF family; E=0; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
      
 0.550
RB950
Amino acid transporter; PMID: 3146645 best DB hits: BLAST: swissprot:Q10858; YJ99_MYCTU HYPOTHETICAL 45.3 KDA TRANSPORT; E=2e-23 embl:CAB76881.1; (AL159139) putative amino acid transporter; E=2e-16 pir:G82809; amino acid transporter XF0408 [imported] - Xylella; E=3e-15 COG: Rv1999c; COG0531 Amino acid transporters; E=2e-24 BS_gabP; COG1113 Gamma-aminobutyrate and related permeases; E=2e-06 Rv3253c; COG0531 Amino acid transporters; E=4e-06 PFAM: PF00324; Amino acid permease; E=0.00042.
      
 0.540
lpxB
lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
       0.528
GALNS
N-acetylgalactosamine 6-sulfate sulfatase (GALNS); PMID: 1755850 PMID: 8001980 PMID: 1522213 best DB hits: BLAST: ddbj:BAA04535.1; (D17629) N-acetylgalactosamine 6-sulfate; E=1e-31 gb:AAF63858.1; (AF112242) N-acetylgalactosamine-6-sulfate; E=4e-30 embl:CAA36398.1; (X52150) arylsulphatase a [Homo sapiens]; E=8e-28 COG: ydeN; COG3119 Arylsulfatase A and related enzymes; E=3e-26 PFAM: PF00884; Sulfatase; E=7.7e-45.
  
   
0.488
GALNS-5
N-acetylgalactosamine 6-sulfate sulfatase (GALNS); PMID: 1755850 PMID: 8001980 PMID: 1522213 PMID: 7668283 PMID: 7795586 best DB hits: BLAST: ddbj:BAA04535.1; (D17629) N-acetylgalactosamine 6-sulfate; E=4e-24 gb:AAF63858.1; (AF112242) N-acetylgalactosamine-6-sulfate; E=4e-23 gb:AAF58475.1; (AE003821) CG8646 gene product [Drosophila; E=1e-22 COG: ydeN; COG3119 Arylsulfatase A and related enzymes; E=1e-14 PFAM: PF00884; Sulfatase; E=9.4e-37.
  
   
0.481
GALNS-6
Probable sulfatase atsG; PMID: 9634230 best DB hits: BLAST: gb:AAF63858.1; (AF112242) N-acetylgalactosamine-6-sulfate; E=8e-20 ddbj:BAA04535.1; (D17629) N-acetylgalactosamine 6-sulfate; E=3e-18 pir:F70837; probable sulfatase (EC 3.1.6.-) atsG - Mycobacterium; E=2e-15 COG: Rv0296c; COG3119 Arylsulfatase A and related enzymes; E=2e-16 BS_yvgJ; COG1368 Phosphoglycerol transferase and related proteins,; E=0.001 PAB0793; COG2194 Predicted membrane-associated, metal-dependent; E=0.002 PFAM: PF01663; Type I phosphodiesterase / nucle; E=0.89 PF00884; Sulfatase; E=7.3e-28.
  
   
0.479
GALNS-4
N-acetylgalactosamine 6-sulfate sulfatase (GALNS); PMID: 8020961 PMID: 1755850 PMID: 8001980 PMID: 1522213 best DB hits: BLAST: gb:AAF49287.1; (AE003522) CG7402 gene product [Drosophila; E=2e-38 gb:AAF49302.1; (AE003522) CG5584 gene product [Drosophila; E=2e-37 ddbj:BAA04535.1; (D17629) N-acetylgalactosamine 6-sulfate; E=2e-35 COG: PA0183; COG3119 Arylsulfatase A and related enzymes; E=2e-31 PFAM: PF00884; Sulfatase; E=2.4e-44.
  
   
0.464
RB13157
Mucin-desulfating sulfatase; PMID: 9710560 PMID: 10809675 best DB hits: BLAST: gb:AAF72520.1; AF248951_1 (AF248951) mucin-desulfating sulfatase; E=6e-35 gb:AAF55296.1; (AE003712) Sulf1 gene product [Drosophila; E=2e-28 pir:T16584; hypothetical protein K09C4.8 - Caenorhabditis elegans; E=3e-24 COG: yidJ; COG3119 Arylsulfatase A and related enzymes; E=1e-24 BS_yqgS; COG1368 Phosphoglycerol transferase and related proteins,; E=0.007 PFAM: PF02455; Hexon-associated protein (IIIa); E=0.25 PF00884; Sulfatase; E=8e-47.
  
   
0.456
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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