STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
mqnEConserved hypothetical protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)    
Predicted Functional Partners:
mqnA
Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
  
 0.984
trzA
Probable chlorohydrolase; PMID: 7592318 best DB hits: BLAST: ddbj:BAB05411.1; (AP001512) BH1692~unknown conserved protein in; E=1e-18 swissprot:Q9RW45; Y824_DEIRA HYPOTHETICAL PROTEIN DR0824 -----; E=1e-16 swissprot:O27549; YF05_METTH HYPOTHETICAL PROTEIN MTH1505 -----; E=5e-16 COG: BH1692; COG0402 Cytosine deaminase and related metal-dependent; E=1e-19 PFAM: PF00744; Dihydroorotase-like; E=0.025 PF01979; Adenine deaminase; E=0.099 PF00962; Adenosine/AMP deaminase; E=0.05.
 
  
  0.968
ubiA
PMID: 1644192 best DB hits: BLAST: gb:AAB41844.1; (U61168) 4-hydroxybenzoate octaprenyltransferase; E=3e-34 ddbj:BAB05369.1; (AP001512) 4-hydroxybenzoate; E=4e-34 pir:E70304; 4-hydroxybenzoate octaprenyltransferase - Aquifex; E=2e-31 COG: BH1650; COG0382 4-hydroxybenzoate polyprenyltranferase; E=4e-35 AF2036; COG0109 Polyprenyltransferase (cytochrome oxidase assembly; E=0.006 PFAM: PF01040; UbiA prenyltransferase family; E=2e-37.
 
   
 0.941
ubiX
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
   
 0.889
thiG
Thiamin biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.875
thiC
Thiamine biosynthesis protein THIC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.831
thiE
Probable thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.825
mqnD
Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily.
 
   
 0.819
RB12506
Probable anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); PMID: 9266669 best DB hits: BLAST: ddbj:BAB05255.1; (AP001512) anti-sigma F factor antagonist (stage; E=0.003 pir:S75220; hypothetical protein slr1912 - Synechocystis sp. (strain; E=0.024 COG: BH1536; COG1366 Anti-anti-sigma regulatory factor (antagonist of; E=3e-04 PFAM: PF01740; STAS domain; E=4.9e-06.
  
    0.819
RB1764
Conserved hypothetical protein-putative transcription regulator; Best DB hits: BLAST: gb:AAG59798.1; AF292097_4 (AF292097) SenB [Leptospira interrogans]; E=4e-06 gb:AAC23717.1; (AF031161) transcriptional activator [Pseudomonas; E=0.004 pir:C82379; response regulator VCA1086 [imported] - Vibrio cholerae; E=0.005 COG: VCA1086_2; COG2208 Serine phosphatase RsbU, regulator of sigma; E=5e-04 TP0995; COG0664 cAMP-binding domains - Catabolite gene activator and; E=0.002 PFAM: PF00072; Response regulator receiver doma; E=0.29 PF02518; Histidine kinase-, DNA gyrase B-; E=0.65.
   
    0.816
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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