STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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glnDUridylyltransferase/uridylyl-removing enzyme glnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (883 aa)    
Predicted Functional Partners:
glnB-2
Nitrogen regulatory protein P-II; PMID: 2907369 PMID: 2885322 PMID: 2907369 PMID: 8226691 best DB hits: BLAST: pir:D82102; nitrogen regulatory protein P-II VC2239 [imported] -; E=9e-35 pir:H81961; nitrogen regulatory protein P-II 1 NMA0447 [imported] -; E=3e-34 pir:B81019; nitrogen regulatory protein P-II NMB1995 [imported] -; E=3e-34 COG: VC2239; COG0347 Nitrogen regulatory protein PII; E=9e-36 PFAM: PF00543; Nitrogen regulatory protein P-II; E=7.7e-53; Belongs to the P(II) protein family.
 
 
 0.993
glnB-4
Nitrogen regulatory protein P-II; PMID: 7590157 PMID: 9733647 best DB hits: BLAST: swissprot:Q10960; GLNB_MYCTU NITROGEN REGULATORY PROTEIN P-II; E=5e-16 swissprot:O30794; GLNB_NOSPU NITROGEN REGULATORY PROTEIN P-II (PII; E=4e-15 swissprot:P80016; GLNB_SYNP7 NITROGEN REGULATORY PROTEIN P-II (PII; E=5e-15 COG: Rv2919c; COG0347 Nitrogen regulatory protein PII; E=5e-17 PFAM: PF00543; Nitrogen regulatory protein P-II; E=1.2e-10.
 
 
 0.975
glnB
Nitrogen regulatory protein P-II; PMID: 2574599 best DB hits: BLAST: swissprot:Q52905; GLNB_RHIME NITROGEN REGULATORY PROTEIN P-II; E=3e-18 gb:AAD56036.1; AF182395_2 (AF182395) P-II regulatory protein; E=1e-17 swissprot:P21193; GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II; E=1e-17 COG: NMB1995; COG0347 Nitrogen regulatory protein PII; E=7e-18 PFAM: PF00543; Nitrogen regulatory protein P-II; E=5.6e-25.
 
 
 0.968
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.787
RB2976
Conserved hypothetical protein; PMID: 10484179 best DB hits: BLAST: gb:AAG19830.1; (AE005068) Vng1547c [Halobacterium sp. NRC-1]; E=2e-29 ddbj:BAB05314.1; (AP001512) BH1595~unknown conserved protein; E=3e-29 pir:G83096; conserved hypothetical protein PA4399 [imported] -; E=8e-29 COG: VNG1547C; COG2096 Uncharacterized ACR; E=2e-30 PFAM: PF01923; Protein of unknown function DUF80; E=6.9e-58; Belongs to the Cob(I)alamin adenosyltransferase family.
       0.677
glnB-3
Nitrogen regulatory protein P-II; PMID: 1702507 best DB hits: BLAST: pir:A72380; nitrogen regulatory protein P-II - Thermotoga maritima; E=4e-21 swissprot:P21193; GLNB_AZOBR NITROGEN REGULATORY PROTEIN P-II; E=8e-17 embl:CAA63238.1; (X92496) PII-like protein Pz [Azospirillum; E=1e-16 COG: TM0403; COG0347 Nitrogen regulatory protein PII; E=4e-22 PFAM: PF00543; Nitrogen regulatory protein P-II; E=2.7e-27.
 
 
 
 0.586
gltB
Glutamate synthase [NADPH] large chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: swissprot:Q06434; GLSF_ANTSP FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE; E=0.0 swissprot:P23225; GLSF_MAIZE FERREDOXIN-DEPENDENT GLUTAMATE; E=0.0 swissprot:Q03460; GLSN_MEDSA GLUTAMATE SYNTHASE [NADH], CHLOROPLAST; E=0.0 COG: sll1502_2; COG0069 Glutamate synthetase domain 2; E=0.0 sll1502_1; COG0067 Glutamate synthetase domain 1; E=1e-118 PFAM: PF01645; Conserved region in glutamate; E=5.5e-235 PF01493; Domain of unknown function DU; E=4.2e-95.
     
 0.549
RB2978
Probable MutT-family protein; PMID: 8843436 best DB hits: BLAST: embl:CAC16440.1; (AL450165) putative MutT-family protein; E=2e-05 swissprot:P56380; AP4A_MOUSE BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE; E=5e-05 pir:F75532; MutTnudix family protein - Deinococcus radiodurans; E=3e-04 COG: DR0329; COG0494 NTP pyrophosphohydrolases including oxidative damage; E=3e-05 DR0004; COG0494 NTP pyrophosphohydrolases including oxidative; E=4e-05 DR0550; COG0494 NTP pyrophosphohydrolases including oxidative damage; E=1e-04 PFAM: PF00293; MutT-like domain; E=4.8e-17.
 
     0.535
gspA
PMID: 10952301 best DB hits: BLAST: pir:C82076; general secretion pathway protein A VC2445 [imported] -; E=8e-18 pir:H82326; MSHA biogenesis protein MshM VC0403 [imported] - Vibrio; E=2e-16 swissprot:P45754; GSPA_AERHY GENERAL SECRETION PATHWAY PROTEIN A; E=2e-14 COG: VC2445_1; COG3267 General secretion pathway protein A; E=7e-19 PFAM: PF00719; Inorganic pyrophosphatase; E=0.73 PF00004; ATPase family associated with; E=0.011.
  
     0.454
RB10916
Outer membrane protein homolog; PMID: 9403685 best DB hits: BLAST: pir:B70199; outer membrane protein homolog - Lyme disease spirochete; E=6e-17 pir:C70412; outer membrane protein - Aquifex aeolicus -----gb:; E=3e-16 gb:AAA96788.1; (U51683) OMP1 precursor [Brucella abortus]; E=2e-15 COG: BB0795; COG0729 Predicted outer membrane protein; E=6e-18 PFAM: PF01103; Bacterial surface antigen; E=1.3e-16.
 
    0.421
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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