STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hupProbable DNA-binding protein HU; PMID: 1644313 PMID: 7765961 PMID: 6300069 PMID: 3566914 PMID: 6540370 PMID: 7500343 best DB hits: BLAST: swissprot:P02346; DBH_BACST DNA-BINDING PROTEIN II (HB) (HU); E=2e-13 prf:1702428A; DNA binding protein HU [Bacillus caldolyticus]; E=1e-12 swissprot:P08821; DBH_BACSU DNA-BINDING PROTEIN II (HB) (HU); E=4e-12 COG: BS_hbs; COG0776 Bacterial nucleoid DNA-binding protein; E=4e-13 PFAM: PF00216; Bacterial DNA-binding protein; E=2.5e-29; Belongs to the bacterial histone-like protein family. (139 aa)    
Predicted Functional Partners:
RB3280
Hypothetical protein-transmembrane prediction.
       0.792
RB3277
Hypothetical protein.
       0.773
rpsT
Probable 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA.
  
  
 0.684
rpsO
Probable 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
   
  
 0.626
nusA
N utilization substance protein A; Participates in both transcription termination and antitermination.
 
 
   0.547
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
  
    0.546
RB3283
Conserved hypothetical protein; PMID: 9923682 best DB hits: BLAST: swissprot:Q9ZMG1; Y274_HELPJ HYPOTHETICAL PROTEIN HP0274JHP0259; E=8e-18 swissprot:P56132; Y274_HELPY HYPOTHETICAL PROTEIN HP0274 -----; E=3e-16 pir:C81395; hypothetical protein Cj0496 [imported] - Campylobacter; E=1e-13 COG: jhp0259; COG0727 Predicted Fe-S-cluster oxidoreductase; E=7e-19.
       0.512
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 
 0.511
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
  
 0.463
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.457
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.