STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
melRMelibiose operon regulatory protein; PMID: 2830169 PMID: 2684786 PMID: 1445207 PMID: 9108148 best DB hits: BLAST: gb:AAC24510.1; (AF049243) regulatory protein [Mesorhizobium loti]; E=2e-25 swissprot:P10411; MELR_ECOLI MELIBIOSE OPERON REGULATORY PROTEIN; E=5e-23 ddbj:BAB20427.1; (AB053204) melibiose operon regulatory protein; E=7e-23 COG: melR; COG2207 AraC-type DNA-binding domain-containing proteins; E=5e-24 BS_adaA; COG2169 Adenosine deaminase; E=1e-07 VC1260; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-07 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=4.3e-24. (289 aa)    
Predicted Functional Partners:
RB3549
Probable lactose operon transcription activator; PMID: 9573174 best DB hits: BLAST: ddbj:BAB05677.1; (AP001513) BH1958~unknown conserved protein; E=1e-07 swissprot:O33813; LACR_STAXY LACTOSE OPERON TRANSCRIPTION; E=4e-07 ddbj:BAB07561.1; (AP001520) two-component response regulator; E=6e-07 COG: BH1958; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-08 BH0394; COG2169 Adenosine deaminase; E=2e-06 PA2337; COG2207 AraC-type DNA-binding domain-containing proteins; E=3e-06 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=3.7e-20.
  
   0.761
RB10655
Best DB hits: BLAST: pir:G83352; transcription regulator MtlR PA2337 [imported] -; E=1e-09 pir:S52856; AraC-like protein - Azorhizobium caulinodans -----; E=1e-08 gb:AAF43900.1; (U20115) adpA-like protein [Mycobacterium; E=2e-08 COG: PA2337; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-10 BS_adaA; COG2169 Adenosine deaminase; E=1e-05 araC; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-05 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=1.4e-21.
  
     0.726
RB9879
Best DB hits: BLAST: pir:C83489; probable transcription regulator PA1261 [imported] -; E=6e-26 pir:H83309; probable transcriptional regulator PA2696 [imported] -; E=8e-14 ddbj:BAB04708.1; (AP001510) transcriptional regulator (AraCXylS; E=1e-11 COG: PA1261; COG2207 AraC-type DNA-binding domain-containing proteins; E=5e-27 PFAM: PF00989; PAS domain; E=0.18 PF00165; Bacterial regulatory helix-turn-heli; E=7.6e-24.
  
     0.671
araC-3
Best DB hits: BLAST: pir:T35901; probable araC family transcription regulator -; E=1e-17 swissprot:Q03320; ARAL_STRAT PUTATIVE ARAC-LIKE TRANSCRIPTION; E=2e-16 swissprot:P35319; ARAL_STRLI PUTATIVE ARAC-LIKE TRANSCRIPTION; E=2e-15 COG: ykgD; COG2207 AraC-type DNA-binding domain-containing proteins; E=2e-12 VCA1018_1; COG2169 Adenosine deaminase; E=3e-05 VCA1074; COG2207 AraC-type DNA-binding domain-containing proteins; E=3e-05 PFAM: PF00440; Bacterial regulatory proteins, tetR; E=0.37 PF00165; Bacterial regulatory helix-turn-heli; E=3.5e-25 PF01047; MarR family; E=0.25.
  
     0.660
xylR
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=3e-40 swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=4e-39 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=1e-34 COG: HI1106_1; COG1609 Transcriptional regulators; E=4e-22 HI1106_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=8e-12 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=2.8e-25.
  
 
 0.642
RB3488
Sorbitol dehydrogenase; PMID: 1460002 PMID: 9384377 best DB hits: BLAST: swissprot:Q06004; DHSO_BACSU SORBITOL DEHYDROGENASE (L-IDITOL; E=1e-32 pir:G72376; alcohol dehydrogenase, zinc-containing - Thermotoga; E=2e-27 pir:H71110; probable dehydrogenase - Pyrococcus horikoshii -----; E=9e-25 COG: BS_gutB; COG1063 Threonine dehydrogenase and related Zn-dependent; E=1e-33 PFAM: PF00107; Zinc-binding dehydrogenases; E=2.2e-50.
       0.530
xylR-3
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=3e-49 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=1e-42 swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=3e-42 COG: xylR_1; COG1609 Transcriptional regulators; E=2e-27 xylR_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-15 BS_degA; COG1609 Transcriptional regulators; E=1e-08 PFAM: PF00532; Periplasmic binding proteins; E=0.085 PF00165; Bacterial regulatory helix-tu; E=2e-18.
  
 
 0.487
xylR-2
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=5e-38 swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=8e-38 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=2e-28 COG: HI1106_1; COG1609 Transcriptional regulators; E=1e-23 xylR_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=4e-12 BH3692; COG1609 Transcriptional regulators; E=2e-05 PFAM: PF00165; Bacterial regulatory helix-turn-hel; E=3.1e-16.
  
 
 0.469
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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