STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB3792Sensor histidine kinase; PMID: 11157922 PMID: 10360571 best DB hits: BLAST: pir:C72228; sensor histidine kinase HpkA - Thermotoga maritima; E=1e-16 swissprot:P23545; PHOR_BACSU ALKALINE PHOSPHATASE SYNTHESIS SENSOR; E=2e-16 gb:AAF70313.1; AF260326_2 (AF260326) SrrB [Staphylococcus aureus]; E=3e-16 COG: TM1654_2; COG0642 Sensory transduction histidine kinases; E=1e-17 PFAM: PF00512; His Kinase A (phosphoacceptor) doma; E=1.8e-16 PF02518; Histidine kinase-, DNA gyrase B-, p; E=2e-27. (378 aa)    
Predicted Functional Partners:
RB6686
Two-component response regulator; PMID: 10484179 PMID: 9878437 best DB hits: BLAST: ddbj:BAB06876.1; (AP001517) two-component response regulator; E=9e-39 gb:AAG43239.1; AF123314_2 (AF123314) putative response regulator; E=5e-38 gb:AAG09797.1; AF258346_2 (AF258346) response regulator RegX3; E=7e-38 COG: BH3157; COG0745 Response regulators consisting of a CheY-like; E=9e-40 phoB; COG0745 Response regulators consisting of a CheY-like receiver; E=5e-31 BH1580; COG0745 Response regulators consisting of a CheY-like; E=1e-30 PFAM: PF00072; Response regulator receiver doma; E=8.3e-31 PF00486; [...]
 
   0.858
hydH
Sensor kinase of the HydH/G two-component system; PMID: 2666400 PMID: 11243806 best DB hits: BLAST: gb:AAG59806.1; AF305914_1 (AF305914) HydH [Klebsiella oxytoca]; E=2e-23 gb:AAG09417.1; AF180147_9 (AF180147) bZIP histidine kinase TobS; E=5e-23 embl:CAB43735.1; (Y18245) bZIP histidine kinase [Pseudomonas; E=6e-23 COG: BH1920; COG0642 Sensory transduction histidine kinases; E=2e-22 PFAM: PF00072; Response regulator receiver doma; E=1.2e-21 PF00989; PAS domain; E=1e-08 PF00785; PAC motif; E=0.053.
 
 
 0.834
RB6217
Putative response regulator; PMID: 10376842 best DB hits: BLAST: gb:AAD28578.1; AF121341_2 (AF121341) putative response regulator; E=7e-27 gb:AAA87378.1; (L42554) pleD gene product [Caulobacter; E=3e-21 pir:S74913; sensory transduction system regulatory protein slr1400 -; E=4e-21 COG: slr1400_1; COG0784 CheY-like receiver domains; E=4e-20 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-19 VC0622_4; COG0784 CheY-like receiver domains; E=4e-19 PFAM: PF00072; Response regulator receiver doma; E=3.1e-37.
 
   0.833
RB5478
Putative two-component system response regulator; PMID: 7699720 best DB hits: BLAST: embl:CAB88489.1; (AL353816) putative two-component systen; E=1e-15 gb:AAB06615.1; (U53173) MviA [Salmonella typhimurium]; E=2e-14 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=1e-13 COG: slr0115; COG0745 Response regulators consisting of a CheY-like; E=1e-13 XF1952_3; COG0784 CheY-like receiver domains; E=3e-13 Rv0981; COG0745 Response regulators consisting of a CheY-like; E=3e-12 PFAM: PF00072; Response regulator receiver doma; E=2.4e-27.
 
   0.832
RB5943
Probable response regulator; PMID: 7699720 PMID: 1454550 best DB hits: BLAST: embl:CAA47908.1; (X67676) phoP [Bacillus subtilis]; E=1e-15 gb:AAA22661.1; (M16775) phoP protein (put.); putative [Bacillus; E=1e-15 swissprot:P13792; PHOP_BACSU ALKALINE PHOSPHATASE SYNTHESIS; E=1e-15 COG: BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=1e-16 sll0043_4; COG0784 CheY-like receiver domains; E=4e-15 Rv0757; COG0745 Response regulators consisting of a CheY-like; E=4e-15 PFAM: PF00072; Response regulator receiver doma; E=4.8e-28.
 
   0.829
cheY-3
Two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB90891.1; (AL355753) two-component system response; E=4e-40 swissprot:P37478; YYCF_BACSU HYPOTHETICAL 27.2 KD SENSORY; E=5e-40 gb:AAD10263.1; (AF036966) putative response regulator; E=9e-40 COG: BS_yycF; COG0745 Response regulators consisting of a CheY-like; E=5e-41 ompR; COG0745 Response regulators consisting of a CheY-like receiver; E=8e-37 TM1655; COG0745 Response regulators consisting of a CheY-like; E=7e-36 PFAM: PF00072; Response regulator receiver doma; E=3.9e-38 PF00486; Transcriptional regulator [...]
 
   0.829
RB5472
Probable two-component system response regulator; PMID: 1454550 best DB hits: BLAST: embl:CAB94653.1; (AL359215) putative two-component system; E=3e-12 pir:D72374; response regulator - Thermotoga maritima (strain MSB8); E=2e-11 embl:CAC04498.1; (AL391588) putative two-component system; E=5e-11 COG: TM0468; COG0784 CheY-like receiver domains; E=2e-12 BS_phoP; COG0745 Response regulators consisting of a CheY-like; E=3e-11 slr0322_3; COG0784 CheY-like receiver domains; E=3e-10 PFAM: PF00072; Response regulator receiver doma; E=9.1e-23.
 
   0.828
RB2621
Phosphate regulon response regulator PhoB; PMID: 10629178 PMID: 3537313 PMID: 9878437 best DB hits: BLAST: gb:AAF15533.1; AF196490_3 (AF196490) phosphate regulon response; E=2e-35 swissprot:Q52990; PHOB_RHIME PHOSPHATE REGULON TRANSCRIPTIONAL; E=2e-31 embl:CAA11074.1; (AJ223073) phosphate regulatory protein; E=9e-31 COG: PA5360; COG0745 Response regulators consisting of a CheY-like; E=5e-31 phoB; COG0745 Response regulators consisting of a CheY-like receiver; E=7e-31 TM1655; COG0745 Response regulators consisting of a CheY-like; E=1e-30 PFAM: PF00072; Response regulator receiver doma; [...]
 
   0.827
phoB
Probable regulatory components of sensory transduction system; PMID: 8905231 best DB hits: BLAST: embl:CAA11074.1; (AJ223073) phosphate regulatory protein; E=3e-11 pir:B70152; response regulatory protein (rrp-1) homolog - Lyme; E=1e-10 gb:AAD30120.2; (AF135389) DNA binding response regulator RpaA; E=2e-10 COG: BB0419_1; COG0784 CheY-like receiver domains; E=1e-11 slr0115; COG0745 Response regulators consisting of a CheY-like; E=2e-10 slr1305_1; COG0784 CheY-like receiver domains; E=3e-09 PFAM: PF00072; Response regulator receiver doma; E=1.4e-18.
 
   0.824
RB11976
PMID: 10984043 best DB hits: BLAST: pir:B83500; probable two-component response regulator PA1157; E=3e-51 pir:F82213; DNA-binding response regulator VC1320 [imported] -; E=4e-41 pir:C83420; probable two-component response regulator PA1799; E=3e-39 COG: PA1157; COG0745 Response regulators consisting of a CheY-like; E=3e-52 rstA; COG0745 Response regulators consisting of a CheY-like receiver; E=5e-34 BS_yclJ; COG0745 Response regulators consisting of a CheY-like; E=8e-34 PFAM: PF00072; Response regulator receiver doma; E=4e-27 PF00486; Transcriptional regulatory prote; E=2.7e-17.
 
   0.811
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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