STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB5275Probable transcription regulator; PMID: 8451183 best DB hits: BLAST: pir:C83489; probable transcription regulator PA1261 [imported] -; E=1e-39 gb:AAF43900.1; (U20115) adpA-like protein [Mycobacterium; E=2e-10 pir:T43707; hypothetical protein [imported] - Streptomyces; E=2e-09 COG: PA1261; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-40 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=2.7e-22. (273 aa)    
Predicted Functional Partners:
RB3653
Transcription regulator; PMID: 10952301 best DB hits: BLAST: pir:F82388; transcription regulator AraCXylS family VCA1001; E=3e-25 pir:C83237; probable transcription regulator PA3269 [imported] -; E=2e-24 embl:CAB88172.1; (AL352972) putative araC-family regulatory; E=1e-23 COG: VCA1001; COG2207 AraC-type DNA-binding domain-containing proteins; E=2e-26 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=3e-20.
  
     0.754
xylR
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=3e-40 swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=4e-39 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=1e-34 COG: HI1106_1; COG1609 Transcriptional regulators; E=4e-22 HI1106_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=8e-12 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=2.8e-25.
  
 
 0.704
araC-3
Best DB hits: BLAST: pir:T35901; probable araC family transcription regulator -; E=1e-17 swissprot:Q03320; ARAL_STRAT PUTATIVE ARAC-LIKE TRANSCRIPTION; E=2e-16 swissprot:P35319; ARAL_STRLI PUTATIVE ARAC-LIKE TRANSCRIPTION; E=2e-15 COG: ykgD; COG2207 AraC-type DNA-binding domain-containing proteins; E=2e-12 VCA1018_1; COG2169 Adenosine deaminase; E=3e-05 VCA1074; COG2207 AraC-type DNA-binding domain-containing proteins; E=3e-05 PFAM: PF00440; Bacterial regulatory proteins, tetR; E=0.37 PF00165; Bacterial regulatory helix-turn-heli; E=3.5e-25 PF01047; MarR family; E=0.25.
  
     0.698
melR-2
Melibiose operon regulatory protein; PMID: 2830169 PMID: 1445207 best DB hits: BLAST: gb:AAC24510.1; (AF049243) regulatory protein [Mesorhizobium loti]; E=5e-37 swissprot:P10411; MELR_ECOLI MELIBIOSE OPERON REGULATORY PROTEIN; E=6e-28 ddbj:BAB20427.1; (AB053204) melibiose operon regulatory protein; E=9e-28 COG: melR; COG2207 AraC-type DNA-binding domain-containing proteins; E=6e-29 BS_adaA; COG2169 Adenosine deaminase; E=6e-10 VC1825; COG2207 AraC-type DNA-binding domain-containing proteins; E=2e-09 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=1.8e-24.
  
     0.697
RB3549
Probable lactose operon transcription activator; PMID: 9573174 best DB hits: BLAST: ddbj:BAB05677.1; (AP001513) BH1958~unknown conserved protein; E=1e-07 swissprot:O33813; LACR_STAXY LACTOSE OPERON TRANSCRIPTION; E=4e-07 ddbj:BAB07561.1; (AP001520) two-component response regulator; E=6e-07 COG: BH1958; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-08 BH0394; COG2169 Adenosine deaminase; E=2e-06 PA2337; COG2207 AraC-type DNA-binding domain-containing proteins; E=3e-06 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=3.7e-20.
  
   0.671
xylR-3
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=3e-49 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=1e-42 swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=3e-42 COG: xylR_1; COG1609 Transcriptional regulators; E=2e-27 xylR_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=1e-15 BS_degA; COG1609 Transcriptional regulators; E=1e-08 PFAM: PF00532; Periplasmic binding proteins; E=0.085 PF00165; Bacterial regulatory helix-tu; E=2e-18.
  
 
 0.647
dapA-3
Probable dihydrodipicolinate synthase; PMID: 1463470 best DB hits: BLAST: pir:D81141; dihydrodipicolinate synthase NMB0929 [imported] -; E=3e-09 pir:H81878; probable dihydrodipicolinate synthase (EC 4.2.1.52); E=4e-09 ddbj:BAB05461.1; (AP001513) dihydrodipicolinate synthase; E=1e-07 COG: NMB0929; COG0329 Dihydrodipicolinate synthetase/N-acetylneuraminate; E=3e-10 PFAM: PF01137; RNA 3'-terminal phosphate cyclase; E=0.88 PF00701; Dihydrodipicolinate synthetase famil; E=0.00018; Belongs to the DapA family.
 
     0.635
RB6542
Xylose operon regulatory protein; PMID: 8041620 best DB hits: BLAST: swissprot:P37390; XYLR_ECOLI XYLOSE OPERON REGULATORY PROTEIN; E=9e-48 swissprot:P45043; XYLR_HAEIN XYLOSE OPERON REGULATORY PROTEIN; E=1e-43 ddbj:BAB03212.1; (AB046360) putative xylose operon regulatory; E=8e-38 COG: xylR_1; COG1609 Transcriptional regulators; E=3e-25 xylR_2; COG2207 AraC-type DNA-binding domain-containing proteins; E=7e-17 PA2320; COG1609 Transcriptional regulators; E=4e-08 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=2.1e-20.
  
    0.627
RB3345
Activator protein MtlR; PMID: 9666063 best DB hits: BLAST: pir:G83352; transcription regulator MtlR PA2337 [imported] -; E=3e-30 gb:AAC34292.1; (AF047527) activator protein [Pseudomonas; E=2e-26 pir:G82221; transcription regulator AraCXylS family VC1260; E=2e-16 COG: PA2337; COG2207 AraC-type DNA-binding domain-containing proteins; E=3e-31 PFAM: PF00165; Bacterial regulatory helix-turn-heli; E=3.5e-21.
  
     0.614
dadA
PMID: 7906689 best DB hits: BLAST: pir:F82279; D-amino acid dehydrogenase, small chain VC0786; E=7e-43 pir:A81228; D-amino acid dehydrogenase, small chain NMB0176; E=1e-42 pir:C82001; D-amino-acid dehydrogenase (EC 1.4.99.1) small subunit; E=3e-40 COG: VC0786; COG0665 Glycine/D-amino acid oxidases (deaminating); E=6e-44 PFAM: PF01494; FAD binding domain; E=0.0014 PF02254; KTN NAD-binding domain; E=0.056 PF02032; Phytoene dehydrogenase related; E=0.013.
       0.560
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.