STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ftsH-2Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (728 aa)    
Predicted Functional Partners:
folE
GTP cyclohydrolase I; PMID: 1551827 PMID: 95352066 best DB hits: BLAST: swissprot:P19465; GCH1_BACSU GTP CYCLOHYDROLASE I (GTP-CH-I); E=1e-59 ddbj:BAB05365.1; (AP001512) GTP cyclohydrolase I [Bacillus; E=1e-57 swissprot:O06273; GCH1_MYCTU GTP CYCLOHYDROLASE I (GTP-CH-I); E=4e-53 COG: BS_mtrA; COG0302 GTP cyclohydrolase I; E=1e-60 PFAM: PF01227; GTP cyclohydrolase I; E=2.3e-110.
 
  
 0.780
hpt
Hypoxanthine-guanine phosphoribosyltransferase; PMID: 10192928 best DB hits: BLAST: pir:T36331; probable hypoxanthine phosphoribosyltransferase -; E=6e-27 ddbj:BAB03803.1; (AP001507) hypoxanthine-guanine; E=8e-23 embl:CAB60853.1; (AL132877) predicted using Genefinder; E=1e-22 COG: BH0084; COG0634 Hypoxanthine-guanine phosphoribosyltransferase; E=7e-24 BU169; COG0462 Phosphoribosylpyrophosphate synthetase; E=0.002 APE2071; COG2236 Predicted phosphoribosyltransferases; E=0.007 PFAM: PF00156; Phosphoribosyl transferase domai; E=1.5e-15; Belongs to the purine/pyrimidine phosphoribosyltrans [...]
  
  
 0.703
clpX
ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 
  
 0.642
fusA
Elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
  
 0.612
fusA-2
Elongation factor G; PMID: 8070396 PMID: 11054294 best DB hits: BLAST: embl:CAB81852.1; (AL161691) elongation factor G [Streptomyces; E=1e-147 swissprot:O66428; EFG_AQUAE ELONGATION FACTOR G (EF-G) -----; E=1e-145 swissprot:P38525; EFG_THEMA ELONGATION FACTOR G (EF-G) -----; E=1e-145 COG: aq_001; COG0480 Translation elongation and release factors (GTPases); E=1e-146 jhp1118; COG0480 Translation elongation and release factors; E=1e-139 BH0131; COG0480 Translation elongation and release factors (GTPases); E=1e-138 PFAM: PF01894; Uncharacterised protein family UPF; E=0.082 PF00009; Elonga [...]
 
  
 0.578
dnaK
Chaperone protein HscC; PMID: 9735342 best DB hits: BLAST: swissprot:P77319; HSCC_ECOLI CHAPERONE PROTEIN HSCC (HSC62); E=1e-92 gb:AAG54984.1; AE005244_2 (AE005244) putative dnaK protein; E=3e-91 embl:CAA06391.1; (AJ005129) dnaK [Thermotoga maritima]; E=3e-88 COG: ybeW; COG0443 Molecular chaperone; E=1e-93 PFAM: PF01869; BadF/BadG/BcrA/BcrD ATPase fa; E=0.37 PF00012; Hsp70 protein; E=9.1e-147.
 
 
 0.572
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
 
  
 0.572
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
 
   0.565
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
  
 
 0.564
dnaK-4
DnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.563
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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