STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
derProbable GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (472 aa)    
Predicted Functional Partners:
cmk
Cytidylate kinase; PMID: 9126287 best DB hits: BLAST: swissprot:Q49885; KCY_MYCLE CYTIDYLATE KINASE (CK) (CYTIDINE; E=2e-30 swissprot:Q9RC80; KCY_BACHD CYTIDYLATE KINASE (CK) (CYTIDINE; E=5e-30 pir:S75604; pantothenate synthetase panC - Synechocystis sp. (strain; E=3e-29 COG: BH1634; COG0283 Cytidylate kinase; E=5e-31 PFAM: PF02223; Thymidylate kinase; E=0.42 PF00485; Phosphoribulokinase / Uridine; E=0.094 PF01202; Shikimate kinase; E=3.5e-05.
  
 0.987
trmE-2
Probable tRNA modification GTPase; PMID: 1552862 best DB hits: BLAST: swissprot:P25811; THDF_BACSU POSSIBLE THIOPHENE AND FURAN; E=7e-21 gb:AAK06340.1; AE006453_4 (AE006453) GTP-binding protein ThdF; E=3e-20 embl:CAA71458.1; (Y10436) orf452; translated orf similarity to; E=2e-17 COG: BS_thdF; COG0486 Predicted GTPase; E=7e-22 DR2308; COG1160 Predicted GTPases; E=8e-12 TP0550; COG0486 Predicted GTPase; E=1e-11 PFAM: PF00071; Ras family; E=0.77 PF02421; Ferrous iron transport protein B; E=1.3e-05 PF01926; GTPase of unknown function; E=1e-06; Belongs to the TRAFAC class TrmE-Era-EngA-EngB [...]
 
   
 0.922
RB3174
Ribosomal large subunit pseudouridine synthase B; PMID: 7934829 best DB hits: BLAST: swissprot:O67444; YE64_AQUAE HYPOTHETICAL PROTEIN AQ_1464 -----; E=4e-47 pir:T36871; probable pseudouridine synthase - Streptomyces; E=1e-40 swissprot:O33210; YH11_MYCTU HYPOTHETICAL 27.6 KDA PROTEIN RV1711; E=9e-38 COG: aq_1464; COG1187 16S rRNA uridine-516 pseudouridylate synthase and; E=3e-48 PFAM: PF01479; S4 domain; E=3.1e-11 PF00849; RNA pseudouridylate synthase; E=6.5e-13.
 
  
 0.876
obg
GTP-binding protein OBG; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
  
 0.834
typA
PMID: 10567266 best DB hits: BLAST: pir:E75426; GTP-binding translation elongation factor homolog; E=1e-163 pir:H81111; GTP-binding protein TypA NMB1199 [imported] - Neisseria; E=1e-161 pir:D81906; probable GTP-binding protein NMA1370 [imported] -; E=1e-161 COG: DR1198; COG1217 Predicted membrane GTPase involved in stress; E=1e-164 typA; COG1217 Predicted membrane GTPase involved in stress response; E=1e-156 BS_ylaG; COG1217 Predicted membrane GTPase involved in stress; E=1e-155 PFAM: PF00009; Elongation factor Tu family; E=2.1e-91 PF00679; Elongation factor G C-terminus; E=3.9e-06.
  
  
 0.826
hflX
GTP-binding protein Hflx; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
 
   
 0.823
ftsY
Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
 
   
 0.791
RB10778
Putative ATP-binding protein; Best DB hits: BLAST: embl:CAC08270.1; (AL392146) putative ATP-binding protein; E=4e-28.
   
    0.772
RB444
Putative ATP-binding protein; PMID: 8843436 best DB hits: BLAST: embl:CAC08270.1; (AL392146) putative ATP-binding protein; E=1e-37.
   
    0.772
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
   
    0.772
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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