STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoAProbable alkaline phosphatase; PMID: 8454193 PMID: 3537962 PMID: 7022451 best DB hits: BLAST: swissprot:P35483; PPBH_PSEAE ALKALINE PHOSPHATASE H PRECURSOR; E=2e-11 pdb:1ANI; A Chain A, Alkaline Phosphatase (D153h, K328h) -----; E=2e-11 pdb:2ANH; A Chain A, Alkaline Phosphatase (D153h) -----pdb:; E=3e-11 COG: PA3296; COG1785 Alkaline phosphatase; E=2e-12 PFAM: PF00245; Alkaline phosphatase; E=2.2e-09. (628 aa)    
Predicted Functional Partners:
phoD
Probable alkaline phosphatase D; PMID: 8760916 PMID: 25878 best DB hits: BLAST: swissprot:P42251; PPBD_BACSU ALKALINE PHOSPHATASE D PRECURSOR; E=6e-09 pir:F83157; hypothetical protein PA3910 [imported] - Pseudomonas; E=5e-08 pir:T35097; probable secreted alkaline phosphatase - Streptomyces; E=2e-06.
  
 
 0.975
phoD-2
Probable alkaline phosphatase D [Precursor]; PMID: 8760916 best DB hits: BLAST: embl:CAC18240.1; (AL451018) conserved hypothetical protein; E=2e-12 ddbj:BAB10478.1; (AB016888) gene_id:MDH9.6~similar to unknown; E=2e-12 embl:CAB92825.1; (AL356892) hypothetical protein [Streptomyces; E=6e-05.
  
 
 0.975
phoD-3
Alkaline phosphatase D [Precursor]; PMID: 8760916 PMID: 25878 best DB hits: BLAST: swissprot:P42251; PPBD_BACSU ALKALINE PHOSPHATASE D PRECURSOR; E=1e-124 ddbj:BAA06483.1; (D30808) unknown [Bacillus subtilis]; E=1e-110 pir:T50595; probable alkaline phosphatase [imported] - Streptomyces; E=1e-103.
  
 
 0.975
phoD-4
Probable alkaline phosphatase D [Precursor]; PMID: 8760916 best DB hits: BLAST: pir:F83157; hypothetical protein PA3910 [imported] - Pseudomonas; E=6e-05 ddbj:BAA06483.1; (D30808) unknown [Bacillus subtilis]; E=1e-04 swissprot:P42251; PPBD_BACSU ALKALINE PHOSPHATASE D PRECURSOR; E=1e-04.
  
 
 0.975
RB8806
Conserved hypothetical protein-putative 6-pyruvoyl-tetrahydropterin synthase; Best DB hits: BLAST: embl:CAC12079.1; (AL445066) conserved hypothetical protein; E=2e-11 swissprot:Q58668; YC72_METJA HYPOTHETICAL PROTEIN MJ1272 -----; E=1e-10 swissprot:O27296; YC28_METTH HYPOTHETICAL PROTEIN MTH1228 -----; E=2e-10 COG: Ta0950; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=1e-12 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthas; E=0.0016 PF01945; Domain of unknown function; E=0.87.
  
  
  0.926
RB8835
Probable secreted alkaline phosphatase (fragment); Best DB hits: BLAST: embl:CAB99170.1; (AL390188) putative secreted alkaline; E=0.003 embl:CAC18240.1; (AL451018) conserved hypothetical protein; E=0.004 ddbj:BAA06483.1; (D30808) unknown [Bacillus subtilis]; E=0.10 PFAM: PF02908; Purple acid phosphatase, N-term; E=0.89 PF00041; Fibronectin type III domain; E=0.42.
  
 
 0.925
thiE
Probable thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
  0.901
folE
GTP cyclohydrolase I; PMID: 1551827 PMID: 95352066 best DB hits: BLAST: swissprot:P19465; GCH1_BACSU GTP CYCLOHYDROLASE I (GTP-CH-I); E=1e-59 ddbj:BAB05365.1; (AP001512) GTP cyclohydrolase I [Bacillus; E=1e-57 swissprot:O06273; GCH1_MYCTU GTP CYCLOHYDROLASE I (GTP-CH-I); E=4e-53 COG: BS_mtrA; COG0302 GTP cyclohydrolase I; E=1e-60 PFAM: PF01227; GTP cyclohydrolase I; E=2.3e-110.
   
 
  0.900
rsgA
Conserved hypothetical protein-putative GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
     
  0.900
RB5135
6-pyruvoyl tetrahydrobiopterin synthase; Best DB hits: BLAST: swissprot:Q9ZDY5; Y178_RICPR HYPOTHETICAL PROTEIN RP178 -----; E=2e-23 pir:E81913; hypothetical protein NMA0704 [imported] - Neisseria; E=3e-12 pir:G81189; 6-pyruvoyl tetrahydrobiopterin synthase, probable; E=7e-12 COG: RP178; COG0720 6-pyruvoyl-tetrahydropterin synthase; E=2e-24 PFAM: PF01242; 6-pyruvoyl tetrahydropterin synthase; E=1.2e-09.
     
  0.900
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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