STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroB-23-dehydroquinate synthase; PMID: 10910347 best DB hits: BLAST: pir:C82693; 3-dehydroquinate synthase XF1334 [imported] - Xylella; E=7e-24 swissprot:P34002; AROB_PSEAE 3-DEHYDROQUINATE SYNTHASE -----; E=1e-21 ddbj:BAB10417.1; (AB011474) 3-dehydroquinate synthase-like; E=6e-21 COG: XF1334; COG0337 3-dehydroquinate synthetase; E=6e-25 PFAM: PF01761; 3-dehydroquinate synthase; E=2.9e-29. (394 aa)    
Predicted Functional Partners:
aroD
3-dehydroquinate dehydratase / shikimate 5-dehydrogenase precursor; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family.
 
 0.996
aroA
AroA(G) protein (phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase); PMID: 10425687 best DB hits: BLAST: pir:E72388; hypothetical protein TM0343 - Thermotoga maritima; E=3e-85 gb:AAG53674.1; AF318277_2 (AF318277); E=4e-79 ddbj:BAA85151.1; (AB018197) carboxysome formation protein; E=2e-72 COG: TM0343; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=3e-86 BS_aroA_2; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate; E=2e-61 Ta0247; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=6e-56 PFAM: PF00610; Domain found in Dishevelled, Egl; E=0.84 PF00 [...]
 
 
 0.984
aroA-2
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.978
aroK
Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.961
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.957
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
  
 
0.926
aroG
Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).
    
 0.920
RB12713
Hypothetical protein-signal peptide and transmembrane prediction; PMID: 11759840 best DB hits: PFAM: PF01040; UbiA prenyltransferase family; E=2.4e-11.
 
   
 0.784
RB1044
Conserved hypothetical protein-putative metal-dependent hydrolases; Best DB hits: BLAST: pir:T36187; hypothetical protein SCE29.08c - Streptomyces coelicolor; E=6e-52 pir:T34934; hypothetical protein SC3F9.12 SC3F9.12 - Streptomyces; E=9e-47 swissprot:Q58778; YD83_METJA HYPOTHETICAL PROTEIN MJ1383 PRECURSOR; E=7e-19 COG: MJ1383; COG1099 Predicted metal-dependent hydrolases with the; E=6e-20.
 
     0.780
RB538
Best DB hits: BLAST: pir:T34935; hypothetical protein SC3F9.13 SC3F9.13 - Streptomyces; E=2e-43 pir:T36186; hypothetical protein SCE29.07c - Streptomyces coelicolor; E=2e-37.
 
     0.776
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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