STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metBCystathionine gamma-synthase; PMID: 9002610 best DB hits: BLAST: embl:CAA64383.1; (X94756) cystathionine gamma-synthase; E=2e-75 gb:AAF26162.1; AC008261_19 (AC008261) putative cystathionine; E=2e-75 swissprot:P55217; METB_ARATH CYSTATHIONINE GAMMA-SYNTHASE,; E=3e-75 COG: APE1226; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-64 PA5025; COG2873 O-acetylhomoserine sulfhydrylase; E=4e-47 PH1093; COG0626 Cystathionine beta-lyases/cystathionine; E=5e-47 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=4.5e-154. (434 aa)    
Predicted Functional Partners:
metB-2
Cystathionine gamma-lyase homolog; PMID: 9843488 best DB hits: BLAST: pir:T45483; cystathionine gamma-lyase homolog [imported] -; E=9e-93 pir:F83595; probable cystathionine gamma-lyase PA0400 [imported] -; E=1e-92 gb:AAG19548.1; (AE005045) cystathionine alpha synthase; MetB; E=3e-92 COG: PA0400; COG0626 Cystathionine beta-lyases/cystathionine; E=1e-93 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=2.9e-199.
 
  
 
0.979
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.976
cysK
Cysteine synthase (O-acetylserine sulfhydrylase); PMID: 10930739 best DB hits: BLAST: gb:AAG01804.1; AF276772_3 (AF276772) O-acetylserine sulfhydrylase; E=3e-83 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=1e-82 pir:H81161; probable cysteine synthase (EC 4.2.99.8) NMA0974; E=1e-81 COG: Rv2334; COG0031 Cysteine synthase; E=1e-83 PFAM: PF00291; Pyridoxal-phosphate dependent enzym; E=1.3e-119.
 
 0.963
cysM
Cysteine synthase B; PMID: 2188958 best DB hits: BLAST: swissprot:P16703; CYSM_ECOLI CYSTEINE SYNTHASE B (O-ACETYLSERINE; E=1e-30 pir:D82758; cysteine synthase XF0831 [imported] - Xylella fastidiosa; E=1e-30 swissprot:P95230; CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE; E=2e-30 COG: cysM; COG0031 Cysteine synthase; E=1e-31 PFAM: PF00291; Pyridoxal-phosphate dependent enzyme; E=5.9e-51.
 
 0.962
metX
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; In the C-terminal section; belongs to the MetW family.
 
 0.951
RB8221
O-acetylhomoserine sulfhydrylase; PMID: 7704274 best DB hits: BLAST: ddbj:BAB06322.1; (AP001516) O-acetylhomoserine sulfhydrylase; E=1e-123 pir:D72324; O-acetylhomoserine sulfhydrylase - Thermotoga maritima; E=1e-114 pir:T40463; O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) -; E=1e-110 COG: BH2603; COG2873 O-acetylhomoserine sulfhydrylase; E=1e-124 DR0921; COG0626 Cystathionine beta-lyases/cystathionine; E=7e-63 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=6.3e-204.
 
 
0.939
sahH
Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, ADOHCYASE); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.920
sir
Sulfite reductase; PMID: 8347657 best DB hits: BLAST: swissprot:P30008; SIR_SYNP7 SULFITE REDUCTASE (FERREDOXIN) -----; E=1e-125 ddbj:BAA90857.1; (AB031214) YvgQ [Bacillus halodurans]; E=1e-122 ddbj:BAB04329.1; (AP001509) sulfite reductase (NADPH) [Bacillus; E=1e-122 COG: BH0610; COG0155 Sulfite reductase hemoprotein beta-component; E=1e-123 MTH280_2; COG2221 Oxidoreductase related to nitrite reductase; E=1e-06 PA4130; COG0155 Sulfite reductase hemoprotein beta-component; E=3e-06 PFAM: PF01077; Nitrite and sulphite reductas; E=1.4e-25.
  
 0.919
cysJ
PMID: 2550423 best DB hits: BLAST: pir:G70040; sulfite reductase (NADPH) (EC 1.8.1.2) flavoprotein yvgR; E=8e-80 ddbj:BAB04328.1; (AP001509) sulfite reductase (NADPH) [Bacillus; E=2e-79 gb:AAG57872.1; AE005504_4 (AE005504) sulfite reductase (NADPH),; E=4e-75 COG: BS_yvgR; COG0369 Sulfite reductase flavoprotein subunit; E=8e-81 PA3490; COG2878 Predicted alternative beta subunit of; E=2e-04 PFAM: PF00667; FAD binding domain; E=1.9e-14 PF00175; Oxidoreductase FAD/NAD-binding d; E=2.8e-35.
  
 
 0.916
ilvE
PMID: 3897211 best DB hits: BLAST: swissprot:Q58414; ILVE_METJA PUTATIVE BRANCHED-CHAIN AMINO ACID; E=3e-07 gb:AAB90305.1; (AE001039) branched-chain amino acid; E=2e-05 pir:F69057; branched-chain amino-acid aminotransferase -; E=6e-05 COG: MJ1008; COG0115 Branched-chain amino acid; E=3e-08.
   
 0.912
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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