STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemNCoproporphyrinogen III oxidase; PMID: 10484179 PMID: 7768836 best DB hits: BLAST: ddbj:BAB05062.1; (AP001511) coproporphyrinogen III oxidase; E=1e-32 swissprot:O67886; HEMN_AQUAE OXYGEN-INDEPENDENT COPROPORPHYRINOGEN; E=2e-31 ddbj:BAB10571.1; (AB008265) oxygen-independent; E=6e-30 COG: BH1343; COG0635 Coproporphyrinogen III oxidase and related FeS; E=1e-33 PFAM: PF02473; Oxygen-independent Coproporphy; E=9.5e-08. (466 aa)    
Predicted Functional Partners:
hemN-2
Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 
0.928
hemG
Protoporphyrinogen oxidase; PMID: 7916647 PMID: 7788523 best DB hits: BLAST: gb:AAA67647.1; (M87049) o181 [Escherichia coli]; E=1e-22 swissprot:P27863; HEMG_ECOLI PROTOPORPHYRINOGEN OXIDASE (PPO); E=2e-22 pir:S30741; hypothetical protein o181 - Escherichia coli; E=4e-22 COG: hemG; COG0716 Flavodoxins; E=2e-23 PFAM: PF00258; Flavodoxin; E=0.00015.
    
 0.912
hemY
Protoporphyrinogen IX and coproporphyrinogen III oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
    
 0.906
RB6350
PMID: 10984043 best DB hits: BLAST: pir:E83450; probable cytochrome oxidase subunit (cbb3-type) PA1557; E=1e-134 pir:E81050; cytochrome-c oxidase (EC 1.9.3.1) fixN chain NMB1725; E=1e-132 pir:C83452; probable cytochrome oxidase subunit (cbb3-type) PA1554; E=1e-129 COG: PA1557; COG3278 Cbb3-type cytochrome oxidase, subunit 1; E=1e-135 NMB1724; COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit; E=8e-38 slr1137; COG0843 Heme/copper-type cytochrome/quinol oxidases,; E=6e-12 PFAM: PF00115; Cytochrome C and Quinol oxidase poly; E=3.4e-65 PF02433; Cytochrome C oxidase, mono-heme subu [...]
  
  
 0.897
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
       0.782
RB6486
PMID: 9371463 best DB hits: BLAST: pir:H69064; serinethreonine protein kinase related protein -; E=3e-13 pir:C75264; probable serinethreonine protein kinase - Deinococcus; E=1e-08 swissprot:P42111; YXAL_BACSU HYPOTHETICAL 38.5 KDA PROTEIN IN; E=5e-07 COG: MTH1485; COG1520 Uncharacterized proteins of WD40-like repeat family; E=3e-14 DR2518_2; COG1520 Uncharacterized proteins of WD40-like repeat; E=5e-09 BS_yxaL; COG1520 Uncharacterized proteins of WD40-like repeat family; E=4e-08 PFAM: PF01011; PQQ enzyme repeat; E=0.0066.
 
     0.738
RB9261
Conserved hypothetical protein; Best DB hits: BLAST: ddbj:BAA37082.1; (AB022095) ORF2 [Streptomyces griseus]; E=5e-45 embl:CAC04221.1; (AL391515) conserved hypothetical protein; E=9e-35 pir:G69070; coenzyme F390 synthetase I - Methanobacterium; E=0.004 COG: MTH1528; COG1541 Coenzyme F390 synthetase; E=4e-04 PFAM: PF00031; Cystatin domain; E=0.0015.
  
     0.728
uroD
Uroporphyrinogen III synthase, uroporhyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.719
RB7538
Conserved hypothetical protein; PMID: 20406833 best DB hits: BLAST: pir:A82284; conserved hypothetical protein VC0762 [imported] -; E=0.029 pir:T29127; hypothetical protein SC1F2.18 - Streptomyces coelicolor; E=0.18 pir:H69064; serinethreonine protein kinase related protein -; E=0.49 COG: VC0762; COG1520 Uncharacterized proteins of WD40-like repeat family; E=0.003 PFAM: PF01011; PQQ enzyme repeat; E=0.054.
  
     0.713
RB11660
PMID: 9371463 best DB hits: BLAST: pir:H69064; serinethreonine protein kinase related protein -; E=0.001 pir:T26310; hypothetical protein W09D6.1 - Caenorhabditis elegans; E=0.64 COG: MTH1485; COG1520 Uncharacterized proteins of WD40-like repeat family; E=1e-04 PFAM: PF01011; PQQ enzyme repeat; E=0.047.
  
     0.705
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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