STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
aroD3-dehydroquinate dehydratase / shikimate 5-dehydrogenase precursor; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family. (496 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
 
 0.998
aroB-2
3-dehydroquinate synthase; PMID: 10910347 best DB hits: BLAST: pir:C82693; 3-dehydroquinate synthase XF1334 [imported] - Xylella; E=7e-24 swissprot:P34002; AROB_PSEAE 3-DEHYDROQUINATE SYNTHASE -----; E=1e-21 ddbj:BAB10417.1; (AB011474) 3-dehydroquinate synthase-like; E=6e-21 COG: XF1334; COG0337 3-dehydroquinate synthetase; E=6e-25 PFAM: PF01761; 3-dehydroquinate synthase; E=2.9e-29.
 
 0.996
aroK
Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 0.993
aroA-2
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.992
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.897
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
  
 0.807
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.682
trpG
Anthranilate synthase component II; PMID: 2656657 PMID: 6283099 PMID: 2404959 best DB hits: BLAST: pir:B82835; anthranilate synthase component II XF0211 [imported] -; E=4e-40 swissprot:P06193; PABA_SALTY PARA-AMINOBENZOATE SYNTHASE GLUTAMINE; E=4e-39 pir:NNPS2P; anthranilate synthase (EC 4.1.3.27) component II; E=6e-39 COG: XF0211; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-41 TM0141_1; COG0512 Anthranilate/para-aminobenzoate synthases; E=7e-37 DR1766; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-36 PFAM: PF00117; Glutamine amidotransferase c [...]
 
 
 0.679
pabB
Para-aminobenzoate synthase component I; PMID: 3057324 best DB hits: BLAST: gb:AAG61067.1; AF322013_186 (AF322013) ID893 [Bradyrhizobium; E=7e-72 swissprot:P12679; PABB_KLEAE PARA-AMINOBENZOATE SYNTHASE COMPONENT; E=4e-59 gb:AAG56801.1; AE005404_4 (AE005404) p-aminobenzoate synthetase,; E=2e-57 COG: pabB; COG0147 Anthranilate/para-aminobenzoate synthases component I; E=4e-58 VC1303; COG0147 Anthranilate/para-aminobenzoate synthases component; E=4e-57 VNG0384G; COG0147 Anthranilate/para-aminobenzoate synthases; E=1e-45 PFAM: PF00425; chorismate binding enzyme; E=2.4e-103.
 
  
 0.672
aroA
AroA(G) protein (phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase); PMID: 10425687 best DB hits: BLAST: pir:E72388; hypothetical protein TM0343 - Thermotoga maritima; E=3e-85 gb:AAG53674.1; AF318277_2 (AF318277); E=4e-79 ddbj:BAA85151.1; (AB018197) carboxysome formation protein; E=2e-72 COG: TM0343; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=3e-86 BS_aroA_2; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate; E=2e-61 Ta0247; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=6e-56 PFAM: PF00610; Domain found in Dishevelled, Egl; E=0.84 PF00 [...]
 
  
 0.667
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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