STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDPhosphoribosylamine-glycine ligase; PMID: 8299947 best DB hits: BLAST: pir:T46882; phosphoribosylamine--glycine ligase (EC 6.3.4.13); E=1e-108 pir:I67805; purine synthesis multifunctional protein - mouse -----; E=1e-108 gb:AAC53250.1; (U20892) glycinamide ribonucleotide synthetase; E=1e-107 COG: BH0634; COG0151 Phosphoribosylamine-glycine ligase; E=1e-108 PFAM: PF02844; Phosphoribosylglycinamide syn; E=6.3e-55 PF02842; Phosphoribosylglycinamide syn; E=2.5e-30 PF01837; Domain of unknown function DU; E=0.23. (454 aa)    
Predicted Functional Partners:
purF
Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 0.999
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
 
 0.999
pur3
Phosphoribosylglycinamide formyltransferase; PMID: 95004650 best DB hits: BLAST: embl:CAA52779.2; (X74767) phosphoribosylglycinamide; E=1e-25 swissprot:P52422; PUR3_ARATH PHOSPHORIBOSYLGLYCINAMIDE; E=1e-25 pir:T11574; phosphoribosylglycinamide formyltransferase (EC 2.1.2.2); E=2e-25 COG: aq_857; COG0299 Folate-dependent phosphoribosylglycinamide; E=1e-23 VC1992; COG0788 Formyltetrahydrofolate hydrolase; E=9e-12 Cj0187c; COG0299 Folate-dependent phosphoribosylglycinamide; E=4e-11 PFAM: PF00551; Formyl transferase; E=2.9e-41.
 
 0.999
purM
Phosphoribosylformylglycinamidine cyclo-ligase; PMID: 3015935 PMID: 3530323 best DB hits: BLAST: pir:S75786; phosphoribosylformylglycinamidine cyclo-ligase (EC; E=3e-82 ddbj:BAB04350.1; (AP001509) phosphoribosylaminoimidazole; E=7e-82 swissprot:P12043; PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE; E=8e-77 COG: slr0838; COG0150 Phosphoribosylaminoimidazol (AIR) synthetase; E=3e-83 PFAM: PF00586; AIR synthase related protein, N-term; E=2.2e-55 PF02769; AIR synthase related protein, C-term; E=9.4e-36.
  
 0.998
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (air carboxylase) (airc); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.997
pfaS
PMID: 10548741 best DB hits: BLAST: gb:AAB89983.1; (AE001017) phosphoribosylformylglycinamidine; E=2e-33 ddbj:BAA20816.1; (AB002359) KIAA0361 [Homo sapiens]; E=2e-26 swissprot:O15067; PUR4_HUMAN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE; E=2e-26 COG: AF1260; COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase,; E=1e-34 NMB1996_2; COG0047 Phosphoribosylformylglycinamidine (FGAM); E=3e-22 HI0752_2; COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase,; E=1e-20.
  
 0.997
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; PMID: 10710307 PMID: 8828210 best DB hits: BLAST: ddbj:BAA89448.1; (AB003161); E=3e-61 pir:G81943; probable phosphoribosylaminoimidazolesuccinocarboxamide; E=4e-60 pir:B81161; phosphoribosylaminoimidazole-succinocarboxamide synthase; E=1e-59 COG: NMB0757; COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide; E=1e-60 PFAM: PF01259; SAICAR synthetase; E=2.3e-21.
 
 0.994
purH
Bifunctional purine biosynthesis protein purH; PMID: 3036807 best DB hits: BLAST: swissprot:P12048; PUR9_BACSU BIFUNCTIONAL PURINE BIOSYNTHESIS; E=1e-125 ddbj:BAB04352.1; (AP001509); E=1e-124 gb:AAF33520.1; (AF170176) Salmonella typhimurium; E=1e-118 COG: BS_purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-126 purH; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP; E=1e-119 HI0887; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only; E=1e-118 PFAM: PF02142; MGS-like domain; E=2.2e-46 PF01808; AICARFT/IMPCHase bienzyme; E=1.3e-113.
 
 
 0.977
folD
5,20-methylene-tetrahyrdofolate dehydrogenase (NADP+) / methylentetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
  
 0.953
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
  
 0.949
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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