STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
fbaFructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (343 aa)    
Predicted Functional Partners:
RB2627
Glyceraldehyde 3-phosphate dehydrogenase; PMID: 8557349 best DB hits: BLAST: swissprot:O06822; G3P_MYCTU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46795; G3P_BORBU GLYCERALDEHYDE 3-PHOSPHATE; E=2e-99 swissprot:P46713; G3P_MYCLE GLYCERALDEHYDE 3-PHOSPHATE; E=6e-99 COG: Rv1436; COG0057 Glyceraldehyde-3-phosphate; E=1e-101 PFAM: PF01408; Oxidoreductase family, NAD-bindi; E=0.11 PF00044; Glyceraldehyde 3-phosphate dehyd; E=2.2e-118 PF02800; Glyceraldehyde 3-phosphate dehyd; E=5.5e-109; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 0.990
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
 
 0.989
eno
Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 0.979
pgi
Glucose-6-phosphate isomerase; PMID: 2549364 best DB hits: BLAST: swissprot:P80860; G6PI_BACSU GLUCOSE-6-PHOSPHATE ISOMERASE (GPI); E=6e-53 ddbj:BAB07062.1; (AP001518) glucose-6-phosphate isomerase; E=4e-52 pir:S15937; glucose-6-phosphate isomerase (EC 5.3.1.9) - Bacillus; E=5e-52 COG: BS_pgi; COG0166 Glucose-6-phosphate isomerase; E=6e-54 PFAM: PF00342; Phosphoglucose isomerase; E=6.8e-31.
  
 
 0.976
tkt
Transketolase; PMID: 7859749 best DB hits: BLAST: swissprot:P45694; TKT_BACSU TRANSKETOLASE ----- pir: G69723; E=1e-171 ddbj:BAB06071.1; (AP001515) transketolase [Bacillus halodurans]; E=1e-169 swissprot:Q43848; TKTC_SOLTU TRANSKETOLASE, CHLOROPLAST PRECURSOR; E=1e-164 COG: BS_tkt; COG0021 Transketolase; E=1e-172 PFAM: PF00456; Transketolase, thiamine dipho; E=1.1e-160 PF02779; Transketolase, central domain; E=1.2e-77 PF02780; Transketolase, C-terminal dom; E=1.1e-49; Belongs to the transketolase family.
  
 
 0.969
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
  
 
 0.955
pgk
Phosphoglycerate kinase; PMID: 8021172 best DB hits: BLAST: swissprot:P40924; PGK_BACSU PHOSPHOGLYCERATE KINASE ----- pir:; E=3e-96 swissprot:O52632; PGK_CLOAB PHOSPHOGLYCERATE KINASE -----gb:; E=4e-96 swissprot:P29409; PGKH_SPIOL PHOSPHOGLYCERATE KINASE, CHLOROPLAST; E=2e-93 COG: BS_pgk; COG0126 3-phosphoglycerate kinase; E=3e-97 PFAM: PF00162; Phosphoglycerate kinase; E=8.3e-186; Belongs to the phosphoglycerate kinase family.
  
 
 0.934
pfk
PPi-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
 
 0.930
pfkA
PMID: 99287316 best DB hits: BLAST: pir:G72396; 6-phosphofructokinase, pyrophosphate-dependent -; E=1e-36 pir:S54978; 6-phosphofructokinase (EC 2.7.1.11),; E=9e-32 gb:AAA85791.1; (U11733) pyrophosphate-dependent; E=1e-31 COG: TM0289; COG0205 6-phosphofructokinase; E=1e-37 PFAM: PF00365; Phosphofructokinase; E=0.0021.
  
 
 0.930
fbaB
Fructose-bisphosphate aldolase class I; PMID: 9531482 best DB hits: BLAST: pir:H64976; hypothetical protein b2097 - Escherichia coli (strain; E=1e-119 swissprot:P71295; ALF1_ECOLI FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS; E=1e-119 gb:AAB18249.1; (U73760) dehydrin [Escherichia coli]; E=1e-117 COG: fbaB; COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and; E=1e-120.
    
 0.926
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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