node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RB6812 | gcvH | RB6812 | RB6808 | Hypothetical protein. | Glycine cleavage system H protein 1; PMID: 8552027 best DB hits: BLAST: swissprot:O86566; GCSH_STRCO PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=1e-15 swissprot:Q50607; GCSH_MYCTU PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=6e-12 swissprot:P25855; GCSH_ARATH GLYCINE CLEAVAGE SYSTEM H PROTEIN 1,; E=7e-12 COG: Rv1826; COG0509 Glycine cleavage system H protein (lipoate-binding); E=6e-13 VNG1605G; COG0509 Glycine cleavage system H protein; E=1e-12 gcvH; COG0509 Glycine cleavage system H protein (lipoate-binding); E=2e-12 PFAM: PF01597; Glycine cleavage H-protein; E=8.4e-12. | 0.526 |
RB6812 | thiL | RB6812 | RB6809 | Hypothetical protein. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.526 |
adk-2 | rsgA | RB7867 | RB2968 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Conserved hypothetical protein-putative GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.900 |
adk-2 | thiL | RB7867 | RB6809 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |
gcvH | RB6812 | RB6808 | RB6812 | Glycine cleavage system H protein 1; PMID: 8552027 best DB hits: BLAST: swissprot:O86566; GCSH_STRCO PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=1e-15 swissprot:Q50607; GCSH_MYCTU PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=6e-12 swissprot:P25855; GCSH_ARATH GLYCINE CLEAVAGE SYSTEM H PROTEIN 1,; E=7e-12 COG: Rv1826; COG0509 Glycine cleavage system H protein (lipoate-binding); E=6e-13 VNG1605G; COG0509 Glycine cleavage system H protein; E=1e-12 gcvH; COG0509 Glycine cleavage system H protein (lipoate-binding); E=2e-12 PFAM: PF01597; Glycine cleavage H-protein; E=8.4e-12. | Hypothetical protein. | 0.526 |
gcvH | thiL | RB6808 | RB6809 | Glycine cleavage system H protein 1; PMID: 8552027 best DB hits: BLAST: swissprot:O86566; GCSH_STRCO PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=1e-15 swissprot:Q50607; GCSH_MYCTU PROBABLE GLYCINE CLEAVAGE SYSTEM H; E=6e-12 swissprot:P25855; GCSH_ARATH GLYCINE CLEAVAGE SYSTEM H PROTEIN 1,; E=7e-12 COG: Rv1826; COG0509 Glycine cleavage system H protein (lipoate-binding); E=6e-13 VNG1605G; COG0509 Glycine cleavage system H protein; E=1e-12 gcvH; COG0509 Glycine cleavage system H protein (lipoate-binding); E=2e-12 PFAM: PF01597; Glycine cleavage H-protein; E=8.4e-12. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.773 |
pdxA | ribA | RB7885 | RB12480 | Pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.480 |
pdxA | thiL | RB7885 | RB6809 | Pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.454 |
phoA | rsgA | RB5778 | RB2968 | Probable alkaline phosphatase; PMID: 8454193 PMID: 3537962 PMID: 7022451 best DB hits: BLAST: swissprot:P35483; PPBH_PSEAE ALKALINE PHOSPHATASE H PRECURSOR; E=2e-11 pdb:1ANI; A Chain A, Alkaline Phosphatase (D153h, K328h) -----; E=2e-11 pdb:2ANH; A Chain A, Alkaline Phosphatase (D153h) -----pdb:; E=3e-11 COG: PA3296; COG1785 Alkaline phosphatase; E=2e-12 PFAM: PF00245; Alkaline phosphatase; E=2.2e-09. | Conserved hypothetical protein-putative GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.900 |
phoA | thiE | RB5778 | RB6331 | Probable alkaline phosphatase; PMID: 8454193 PMID: 3537962 PMID: 7022451 best DB hits: BLAST: swissprot:P35483; PPBH_PSEAE ALKALINE PHOSPHATASE H PRECURSOR; E=2e-11 pdb:1ANI; A Chain A, Alkaline Phosphatase (D153h, K328h) -----; E=2e-11 pdb:2ANH; A Chain A, Alkaline Phosphatase (D153h) -----pdb:; E=3e-11 COG: PA3296; COG1785 Alkaline phosphatase; E=2e-12 PFAM: PF00245; Alkaline phosphatase; E=2.2e-09. | Probable thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.901 |
phoA | thiL | RB5778 | RB6809 | Probable alkaline phosphatase; PMID: 8454193 PMID: 3537962 PMID: 7022451 best DB hits: BLAST: swissprot:P35483; PPBH_PSEAE ALKALINE PHOSPHATASE H PRECURSOR; E=2e-11 pdb:1ANI; A Chain A, Alkaline Phosphatase (D153h, K328h) -----; E=2e-11 pdb:2ANH; A Chain A, Alkaline Phosphatase (D153h) -----pdb:; E=3e-11 COG: PA3296; COG1785 Alkaline phosphatase; E=2e-12 PFAM: PF00245; Alkaline phosphatase; E=2.2e-09. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.900 |
ribA | pdxA | RB12480 | RB7885 | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.480 |
ribA | ribD | RB12480 | RB6126 | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | PMID: 9068650 best DB hits: BLAST: pir:T50546; riboflavin bifunctional biosynthesis protein ribG; E=2e-56 swissprot:P50853; RIBD_ACTPL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD; E=2e-56 ddbj:BAB05273.1; (AP001512) riboflavin specific; E=9e-52 COG: ribD_1; COG0117 Pyrimidine deaminase; E=1e-28 BH1554_2; COG1985 Pyrimidine reductase, riboflavin biosynthesis; E=6e-21 CPn0871_1; COG0117 Pyrimidine deaminase; E=1e-20 PFAM: PF00383; Cytidine and deoxycytidylate de; E=1.5e-31 PF01872; RibD C-terminal domain; E=4e-33. | 0.999 |
ribA | thiE | RB12480 | RB6331 | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Probable thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.469 |
ribA | thiL | RB12480 | RB6809 | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.496 |
ribD | ribA | RB6126 | RB12480 | PMID: 9068650 best DB hits: BLAST: pir:T50546; riboflavin bifunctional biosynthesis protein ribG; E=2e-56 swissprot:P50853; RIBD_ACTPL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD; E=2e-56 ddbj:BAB05273.1; (AP001512) riboflavin specific; E=9e-52 COG: ribD_1; COG0117 Pyrimidine deaminase; E=1e-28 BH1554_2; COG1985 Pyrimidine reductase, riboflavin biosynthesis; E=6e-21 CPn0871_1; COG0117 Pyrimidine deaminase; E=1e-20 PFAM: PF00383; Cytidine and deoxycytidylate de; E=1.5e-31 PF01872; RibD C-terminal domain; E=4e-33. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.999 |
ribD | thiD | RB6126 | RB7580 | PMID: 9068650 best DB hits: BLAST: pir:T50546; riboflavin bifunctional biosynthesis protein ribG; E=2e-56 swissprot:P50853; RIBD_ACTPL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD; E=2e-56 ddbj:BAB05273.1; (AP001512) riboflavin specific; E=9e-52 COG: ribD_1; COG0117 Pyrimidine deaminase; E=1e-28 BH1554_2; COG1985 Pyrimidine reductase, riboflavin biosynthesis; E=6e-21 CPn0871_1; COG0117 Pyrimidine deaminase; E=1e-20 PFAM: PF00383; Cytidine and deoxycytidylate de; E=1.5e-31 PF01872; RibD C-terminal domain; E=4e-33. | PMID: 10075431 best DB hits: BLAST: pir:E71057; probable thiamin biosynthesis protein - Pyrococcus; E=4e-45 pir:C75087; hydroxymethylpyrimidine phosphate kinase (thid) PAB1646; E=2e-44 pir:F75613; phosphomethylpyrimidine kinase - Deinococcus radiodurans; E=5e-43 COG: PH1155_1; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine; E=4e-46 thiD; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; E=3e-42 NMB1616; COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine; E=3e-41 PFAM: PF01031; Dynamin central region; E=0.41 PF00294; pfkB family carbohydrate kinase; E=7.7e-08. | 0.441 |
ribD | thiL | RB6126 | RB6809 | PMID: 9068650 best DB hits: BLAST: pir:T50546; riboflavin bifunctional biosynthesis protein ribG; E=2e-56 swissprot:P50853; RIBD_ACTPL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD; E=2e-56 ddbj:BAB05273.1; (AP001512) riboflavin specific; E=9e-52 COG: ribD_1; COG0117 Pyrimidine deaminase; E=1e-28 BH1554_2; COG1985 Pyrimidine reductase, riboflavin biosynthesis; E=6e-21 CPn0871_1; COG0117 Pyrimidine deaminase; E=1e-20 PFAM: PF00383; Cytidine and deoxycytidylate de; E=1.5e-31 PF01872; RibD C-terminal domain; E=4e-33. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.725 |
rsgA | adk-2 | RB2968 | RB7867 | Conserved hypothetical protein-putative GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.900 |
rsgA | phoA | RB2968 | RB5778 | Conserved hypothetical protein-putative GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | Probable alkaline phosphatase; PMID: 8454193 PMID: 3537962 PMID: 7022451 best DB hits: BLAST: swissprot:P35483; PPBH_PSEAE ALKALINE PHOSPHATASE H PRECURSOR; E=2e-11 pdb:1ANI; A Chain A, Alkaline Phosphatase (D153h, K328h) -----; E=2e-11 pdb:2ANH; A Chain A, Alkaline Phosphatase (D153h) -----pdb:; E=3e-11 COG: PA3296; COG1785 Alkaline phosphatase; E=2e-12 PFAM: PF00245; Alkaline phosphatase; E=2.2e-09. | 0.900 |