STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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fabF-33-oxoacyl-(acyl-carrier protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (429 aa)    
Predicted Functional Partners:
fabD
Malonyl CoA-acyl carrier protein transacylase; PMID: 1339356 PMID: 7768883 best DB hits: BLAST: embl:CAB45522.1; (AJ007046) [acyl-carrier protein]; E=9e-58 pir:T00580; probable [acyl-carrier-protein] S-malonyltransferase (EC; E=1e-57 gb:AAG43518.1; AF210698_1 (AF210698) malonyl-CoA:ACP transacylase; E=1e-56 COG: HI0156; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=6e-52 PFAM: PF00698; Acyl transferase domain; E=3.2e-16.
 0.999
fabH-3
3-oxoacyl-(acyl-carrier protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 0.996
fabH-2
3-oxoacyl-(acyl-carrier-protein) synthase III; PMID: 1551888 PMID: 10593943 best DB hits: BLAST: pir:C81029; 3-oxoacyl-(acyl-carrier-protein) synthase III NMB1916; E=7e-41 gb:AAK04869.1; AE006310_11 (AE006310); E=1e-39 pir:H82633; beta-ketoacyl-[ACP] synthase III XF1817 [imported] -; E=3e-39 COG: NMB1916; COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; E=7e-42 PFAM: PF02797; Chalcone and stilbene synthas; E=0.31.
 
 
 0.987
fabZ-2
Probable hydroxymyristoyl-(acyl carrier protein) dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAK04875.1; AE006311_6 (AE006311); E=3e-11 pir:D70065; (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; E=5e-11 gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=9e-11 COG: BS_ywpB; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=5e-12 PFAM: PF01377; Thioester dehydrase; E=6e-11.
 
 
 0.986
fabI
Enoyl-[acyl-carrier-protein] reductase [NADH]; PMID: 8075395 PMID: 8953047 PMID: 10493822 best DB hits: BLAST: gb:AAD04184.1; (L10036) unknown [Nostoc sp. PCC 7120]; E=2e-60 swissprot:Q05069; FABI_ANASP ENOYL-[ACYL-CARRIER-PROTEIN]; E=2e-60 pir:H81284; probable enoyl-[acyl-carrier-protein] reductase [NADH]; E=1e-55 COG: Cj1400c; COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); E=9e-57 BH1511; COG1028 Dehydrogenases with different specificities (related; E=2e-16 BS_yhdF; COG1028 Dehydrogenases with different specificities; E=2e-15 PFAM: PF00106; short chain dehydrogenase; E=0.019 [...]
 
 
 0.985
fabI-2
trans-2-enoyl-ACP reductase; PMID: 20138198 best DB hits: BLAST: gb:AAF05840.1; AF197058_1 (AF197058) trans-2-enoyl-ACP reductase; E=6e-31 ddbj:BAB06562.1; (AP001516) enoyl-[acyl-carrier protein]; E=5e-29 gb:AAD04184.1; (L10036) unknown [Nostoc sp. PCC 7120]; E=2e-28 COG: BH2843; COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); E=5e-30 TM0441; COG1028 Dehydrogenases with different specificities (related; E=1e-09 BS_yfhR; COG1028 Dehydrogenases with different specificities; E=1e-06 PFAM: PF00678; Short chain dehydrogenase/redu; E=7.1e-05.
 
 
 0.984
fabZ-3
Probable hydroxymyristoyl-(acyl carrier protein) dehydratase; PMID: 7806516 best DB hits: BLAST: ddbj:BAB07454.1; (AP001519) hydroxymyristoyl-(acyl carrier; E=4e-09 pir:A70305; (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase; E=5e-09 pir:H71826; (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; E=7e-09 COG: BH3735; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=4e-10 PFAM: PF01377; Thioester dehydrase; E=0.00031.
 
 
 0.979
RB11975
Polyketide synthase; PMID: 10662695 PMID: 10649995 best DB hits: BLAST: gb:AAF26921.1; AF210843_18 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF26923.1; AF210843_20 (AF210843) polyketide synthase [Sorangium; E=0.0 gb:AAF62883.1; AF217189_6 (AF217189) epoD [Sorangium cellulosum]; E=0.0 COG: BS_fabD; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=7e-31 PA2965; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase I; E=3e-28 PA5234; COG0604 NADPH:quinone reductase and related Zn-dependent; E=2e-27 PFAM: PF00108; Thiolase, N-terminal domain; E=7.3e-07 PF00109; Beta-ketoacyl s [...]
  
 
0.969
fabZ-4
Probable beta-hydroxyacyl-ACP dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=2e-14 gb:AAK04875.1; AE006311_6 (AE006311); E=3e-14 pir:C82731; (3r)-hydroxymyristoyl ACP dehydrase XF1044 [imported] -; E=6e-14 COG: XF1044; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=6e-15 PFAM: PF01377; Thioester dehydrase; E=2.1e-18 PF01575; MaoC like domain; E=0.0056.
 
 
 0.962
fabZ
Probable beta-hydroxyacyl-ACP dehydratase; PMID: 7806516 best DB hits: BLAST: gb:AAF98278.1; AF197933_8 (AF197933) beta-hydroxyacyl-ACP; E=1e-05 pir:H81661; (3R)-hydroxymyristol-(acyl carrier protein) dehydratase; E=4e-05 pir:B33171; hypothetical 17K protein (lpxA 5' region) - Escherichia; E=5e-05 COG: fabZ; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier; E=5e-06 PFAM: PF01377; Thioester dehydrase; E=1.3e-15.
 
 
 0.961
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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