STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnIIGlutamine synthetase II; PMID: 2575672 PMID: 1357539 best DB hits: BLAST: swissprot:P04772; GLN2_BRAJA GLUTAMINE SYNTHETASE II; E=1e-103 swissprot:Q02154; GLN2_RHILP GLUTAMINE SYNTHETASE II; E=1e-99 swissprot:P45626; GLN2_RHIME GLUTAMINE SYNTHETASE II; E=9e-97 COG: YPR035w; COG0174 Glutamine synthase; E=5e-83 PFAM: PF00120; Glutamine synthetase; E=3.6e-133. (366 aa)    
Predicted Functional Partners:
gltB
Glutamate synthase [NADPH] large chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: swissprot:Q06434; GLSF_ANTSP FERREDOXIN-DEPENDENT GLUTAMATE SYNTHASE; E=0.0 swissprot:P23225; GLSF_MAIZE FERREDOXIN-DEPENDENT GLUTAMATE; E=0.0 swissprot:Q03460; GLSN_MEDSA GLUTAMATE SYNTHASE [NADH], CHLOROPLAST; E=0.0 COG: sll1502_2; COG0069 Glutamate synthetase domain 2; E=0.0 sll1502_1; COG0067 Glutamate synthetase domain 1; E=1e-118 PFAM: PF01645; Conserved region in glutamate; E=5.5e-235 PF01493; Domain of unknown function DU; E=4.2e-95.
  
 
 0.983
glmS
PMID: 7476196 best DB hits: BLAST: embl:CAB87226.1; (AL163641) glucosamine-fructose-6-phosphate; E=1e-135 pir:T44486; glutamine--fructose-6-phosphate transaminase; E=1e-133 gb:AAF09884.1; AE001891_3 (AE001891); E=1e-132 COG: DR0302; COG0449 Glucosamine 6-phosphate synthetase, contains; E=1e-133 PFAM: PF00310; Glutamine amidotransferases class-II; E=2.1e-65 PF01380; SIS domain; E=2.2e-39.
  
 
 0.942
gltD
NADH-glutamate synthase small chain; PMID: 2643092 PMID: 3326786 best DB hits: BLAST: ddbj:BAA12742.1; (D85230) small subunit of NADH-dependent; E=1e-163 pir:T49818; probable glutamate synthase (NADPH) [imported] -; E=1e-162 pir:S74625; NADH-glutamate synthase small chain gltD - Synechocystis; E=1e-161 COG: sll1027; COG0493 NADPH-dependent glutamate synthase beta chain and; E=1e-162 PFAM: PF01494; FAD binding domain; E=0.013 PF02254; KTN NAD-binding domain; E=0.036 PF00984; UDP-glucose/GDP-mannose dehydr; E=0.28.
  
 
 0.942
nirB
Nitrite reductase [NAD(P)H] large subunit; PMID: 2543955 best DB hits: BLAST: pir:S04349; nitrate reductase (NADH) (EC 1.6.6.1) - Escherichia coli; E=5e-75 swissprot:P08201; NIRB_ECOLI NITRITE REDUCTASE [NAD(P)H] LARGE; E=3e-69 gb:AAG58473.1; AE005559_9 (AE005559) nitrite reductase (NAD(P)H); E=3e-69 COG: nirB; COG1251 NAD(P)H-nitrite reductase; E=3e-70 PH1509; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; E=3e-38 PFAM: PF00070; Pyridine nucleotide-disulphide oxid; E=1.5e-65.
    
 0.937
carA
Carbamoyl-phosphate synthase, small chain; PMID: 2843375 PMID: 6330744 best DB hits: BLAST: pir:E82083; carbamoyl-phosphate synthase, small chain VC2390; E=1e-99 pir:C70337; carbamoyl phosphate synthetase small subunit - Aquifex; E=3e-98 pir:S76783; hypothetical protein - Synechocystis sp. (strain PCC; E=6e-96 COG: VC2390; COG0505 Carbamoylphosphate synthase small subunit; E=1e-100 PFAM: PF00988; Carbamoyl-phosphate synthase; E=8.7e-82 PF00117; Glutamine amidotransferase cl; E=5.7e-62; Belongs to the CarA family.
  
 
 0.937
carB
PMID: 8905231 PMID: 6308632 best DB hits: BLAST: swissprot:P00968; CARB_ECOLI CARBAMOYL-PHOSPHATE SYNTHASE LARGE; E=0.0 pir:S76557; carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC; E=0.0 gb:AAG10606.1; AC008030_6 (AC008030) carbamoyl phosphate synthetase; E=0.0 COG: AF1274; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 carB; COG0458 Carbamoylphosphate synthase large subunit (split gene in; E=0.0 BU144; COG0458 Carbamoylphosphate synthase large subunit (split gene; E=0.0 PFAM: PF00289; Carbamoyl-phosphate synthase L; E=2.9e-53 PF02222; ATP-grasp domain; E [...]
  
 
 0.936
putA
PMID: 96062224 best DB hits: BLAST: pir:H64526; proline dehydrogenase (EC 1.5.99.8); E=0.0 pir:B71980; proline dehydrogenase (EC 1.5.99.8); E=0.0 pir:C81297; proline dehydrogenase (EC 1.5.99.8); E=1e-180 COG: jhp0048_2; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-123 Cj1503c_1; COG0506 Proline dehydrogenase; E=2e-56 sll1561_2; COG1012 NAD-dependent aldehyde dehydrogenases; E=1e-51 PFAM: PF01619; Proline dehydrogenase; E=2e-36 PF00171; Aldehyde dehydrogenase family; E=0.0014; Belongs to the aldehyde dehydrogenase family.
  
 
 0.935
gdhA
Glutamate dehydrogenase A; PMID: 7551585 best DB hits: BLAST: swissprot:O04937; DHEA_NICPL GLUTAMATE DEHYDROGENASE A (GDH A); E=1e-115 swissprot:Q43314; DHE1_ARATH GLUTAMATE DEHYDROGENASE 1 (GDH 1); E=1e-115 pir:T04342; glutamate dehydrogenase (EC 1.4.1.2) - maize -----; E=1e-114 COG: TM1015; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; E=1e-99 PFAM: PF02812; Glu/Leu/Phe/Val dehydrogenase; E=3.1e-56 PF00044; Glyceraldehyde 3-phosphate de; E=0.76 PF02254; KTN NAD-binding domain; E=0.33; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.932
nirA
Ferredoxin--nitrite reductase; PMID: 8490140 best DB hits: BLAST: swissprot:P39661; NIR_SYNP7 FERREDOXIN--NITRITE REDUCTASE -----; E=9e-54 gb:AAF00916.1; AF178846_1 (AF178846) ferredoxin nitrite reductase; E=4e-53 gb:AAC46074.1; (U61496) nitrite reductase [Nostoc sp. PCC 7120]; E=4e-51 COG: slr0898; COG0155 Sulfite reductase hemoprotein beta-component; E=2e-49 BS_nasB; COG1251 NAD(P)H-nitrite reductase; E=0.008 PFAM: PF01077; Nitrite and sulphite reductase 4Fe-4; E=1.7e-16.
  
  
 0.929
purF
Amidophosphoribosyltransferase [precursor]; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.924
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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