STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
lpxKProbable tetraacyldisaccharide 4-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (365 aa)    
Predicted Functional Partners:
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 0.998
lpxB
lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
 0.995
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; PMID: 10910347 PMID: 7775423 best DB hits: BLAST: pir:D82700; 2-dehydro-3-deoxyphosphooctonate aldolase XF1289; E=4e-64 swissprot:O66496; KDSA_AQUAE 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE; E=2e-63 pir:F81381; 2-dehydro-3-deoxyphosphooctonate aldolase (EC 4.1.2.16); E=4e-62 COG: XF1289; COG2877 3-Deoxy-D-manno-octulosonic acid (KDO) 8-phosphate; E=3e-65 sll0934; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP); E=6e-23 BS_aroA_2; COG2876 3-Deoxy-D-arabino-heptulosonate 7-phosphate; E=1e-15 PFAM: PF00793; DAHP synthetase I family; E=9.1e-92.
 
   
 0.938
RB13211
4-amino-4-deoxy-L-arabinose transferase; Best DB hits: BLAST: pir:S77201; hypothetical protein slr1820 - Synechocystis sp. (strain; E=7e-27 gb:AAG57388.1; AE005458_5 (AE005458) orf, hypothetical protein; E=3e-26 pir:G64996; hypothetical protein b2257 - Escherichia coli (strain; E=3e-26 COG: slr1820; COG1807 Uncharacterized protein, affecting LPS biosynthesis; E=7e-28 aq_1899; COG0463 Glycosyltransferases involved in cell wall; E=8e-27 PA3556; COG1807 Uncharacterized protein, affecting LPS biosynthesis; E=1e-22 PFAM: PF00535; Glycosyl transferase; E=7.2e-32 PF02366; Dolichyl-phosphate-m [...]
 
  
 0.937
RB9823
Conserved hypothetical protein; Best DB hits: BLAST: swissprot:O67500; YF46_AQUAE HYPOTHETICAL PROTEIN AQ_1546 -----; E=3e-47 swissprot:P45313; YRBH_HAEIN HYPOTHETICAL PROTEIN HI1678 -----; E=2e-46 gb:AAK02609.1; (AE006087) KpsF [Pasteurella multocida]; E=3e-43 COG: aq_1546_1; COG0794 Predicted sugar phosphate isomerase involved in; E=7e-37 APE1838; COG0517 CBS domains; E=2e-08 PFAM: PF01380; SIS domain; E=1.1e-28 PF00571; CBS domain; E=0.059.
 
   
 0.875
lpdX
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.859
kpsU
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.859
lpxC
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. Belongs to the LpxC family.
 
   
 0.858
lpxA
acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.858
htrB
PMID: 20365717 PMID: 10910347 best DB hits: BLAST: pir:E82847; lipid A biosynthesis lauroyl acyltransferase XF0104; E=8e-07 pir:A81318; probable lipid A biosynthesis lauroyl acyltransferase; E=2e-06 gb:AAG43974.1; AF215659_2 (AF215659) acyltransferase; E=1e-05 COG: XF0104; COG1560 Lauroyl/myristoyl acyltransferase involved in lipid; E=8e-08 RP718; COG1560 Lauroyl/myristoyl acyltransferase involved in lipid A; E=4e-04 CPn0098; COG1560 Lauroyl/myristoyl acyltransferase involved in lipid; E=0.005.
 
  
 0.837
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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