STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (547 aa)    
Predicted Functional Partners:
trpG
Anthranilate synthase component II; PMID: 2656657 PMID: 6283099 PMID: 2404959 best DB hits: BLAST: pir:B82835; anthranilate synthase component II XF0211 [imported] -; E=4e-40 swissprot:P06193; PABA_SALTY PARA-AMINOBENZOATE SYNTHASE GLUTAMINE; E=4e-39 pir:NNPS2P; anthranilate synthase (EC 4.1.3.27) component II; E=6e-39 COG: XF0211; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-41 TM0141_1; COG0512 Anthranilate/para-aminobenzoate synthases; E=7e-37 DR1766; COG0512 Anthranilate/para-aminobenzoate synthases component; E=3e-36 PFAM: PF00117; Glutamine amidotransferase c [...]
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 0.999
trpG-2
Best DB hits: BLAST: swissprot:P20576; TRPG_PSEAE ANTHRANILATE SYNTHASE COMPONENT II; E=1e-60 pir:A35114; trpG protein - Pseudomonas aeruginosa ----- gb:; E=1e-60 pir:NNPS2P; anthranilate synthase (EC 4.1.3.27) component II; E=2e-59 COG: PA0649; COG0512 Anthranilate/para-aminobenzoate synthases component; E=1e-61 pabA; COG0512 Anthranilate/para-aminobenzoate synthases component II; E=3e-56 BS_pabA; COG0512 Anthranilate/para-aminobenzoate synthases component; E=2e-55 PFAM: PF00117; Glutamine amidotransferase class-I; E=2.5e-68.
 0.999
trpC
Indole-3-glycerol phosphate synthase; PMID: 1896020 PMID: 7007653 PMID: 6355484 best DB hits: BLAST: swissprot:P26938; TRPC_AZOBR INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=6e-55 swissprot:P94327; TRPC_BRAJA INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=3e-52 swissprot:Q9ZFA7; TRPC_RHOSH INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; E=2e-51 COG: XF0213; COG0134 Indole-3-glycerol phosphate synthase; E=5e-51 PFAM: PF00218; Indole-3-glycerol phosphate synthase; E=2.6e-111; Belongs to the TrpC family.
 
 0.998
trpF
N-(5-phosphoribosyl)anthranilate isomerase; PMID: 96003619 PMID: 97309356 best DB hits: BLAST: pdb:1DL3; A Chain A, Crystal Structure Of Mutually Generated; E=2e-19 swissprot:Q56320; TRPF_THEMA N-(5'-PHOSPHORIBOSYL)ANTHRANILATE; E=5e-19 pir:E81935; probable phosphoribosylanthranilate isomerase (EC; E=6e-18 COG: TM0139; COG0135 Phosphoribosylanthranilate isomerase; E=5e-20 PFAM: PF00697; N-(5'phosphoribosyl)anthranilate (PR; E=7.3e-41; Belongs to the TrpF family.
 
  
 0.957
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.951
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.950
pheA
P-protein (PheA); PMID: 1919506 best DB hits: BLAST: swissprot:O67085; PHEA_AQUAE P-PROTEIN [INCLUDES: CHORISMATE; E=2e-40 swissprot:P27603; PHEA_PSEST P-PROTEIN [INCLUDES: CHORISMATE; E=8e-40 gb:AAD47360.1; AF038578_3 (AF038578) chorismate mutaseprephenate; E=1e-38 COG: aq_951_2; COG0077 Prephenate dehydratase; E=9e-40 PFAM: PF00800; Prephenate dehydratase; E=4.5e-50 PF01842; ACT domain; E=3.1e-09.
 
  
 0.940
trpB
Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.932
aroH
Chorismate mutase; PMID: 2105742 PMID: 8046752 best DB hits: BLAST: ddbj:BAB05377.1; (AP001512) chorismate mutase [Bacillus; E=6e-26 gb:AAD33790.1; AF139534_1 (AF139534) chorismate mutase [Bacillus; E=5e-25 swissprot:P19080; CHMU_BACSU CHORISMATE MUTASE (CM) ----- pir:; E=1e-22.
    
  0.906
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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