STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknB-7Serine/threonine kinase Pkn10; PMID: 99426839 best DB hits: BLAST: gb:AAF80365.1; AF159160_1 (AF159160) serinethreonine kinase Pkn10; E=6e-50 swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=3e-46 swissprot:P71584; PKNB_MYCTU PUTATIVE SERINETHREONINE-PROTEIN; E=7e-44 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=7e-45 PFAM: PF00069; Protein kinase domain; E=1.6e-64. (611 aa)    
Predicted Functional Partners:
RB8026
Best DB hits: BLAST: pir:E82768; conserved hypothetical protein XF0752 [imported] -; E=4e-30 pir:A82381; conserved hypothetical protein VCA1077 [imported] -; E=1e-26 gb:AAF47337.1; (AE003467) CG7049 gene product [Drosophila; E=5e-19 COG: XF0752_2; COG1262 Uncharacterized BCR; E=9e-30.
 
  
 0.813
RB3245
Protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=3e-27 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=5e-26 embl:CAA10712.1; (AJ132604) pppL protein [Lactococcus lactis]; E=2e-25 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-27 PFAM: PF00481; Protein phosphatase 2C; E=1.2e-09.
  
   0.794
Pph1
Probable protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=9e-32 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=4e-28 pir:H75265; conserved hypothetical protein - Deinococcus radiodurans; E=5e-28 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-29 PFAM: PF00481; Protein phosphatase 2C; E=4.9e-09.
 
   0.792
RB8027
Hypothetical protein.
   
   0.786
RB8018
Hypothetical protein-transmembrane prediction.
       0.686
RB8022
Hypothetical protein-signal peptide prediction.
       0.686
RB5876
Probable serine/threonine-protein kinase; PMID: 7768349 best DB hits: BLAST: swissprot:P54737; PKN5_MYXXA SERINETHREONINE-PROTEIN KINASE PKN5; E=3e-09 gb:AAF87930.1; AF163841_9 (AF163841) putative serinethreonine; E=4e-09 swissprot:P54738; PKN6_MYXXA SERINETHREONINE-PROTEIN KINASE PKN6; E=1e-07 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=1e-07 PFAM: PF00069; Protein kinase domain; E=3.8e-08 PF01130; CD36 family; E=0.61.
  
     0.656
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
      
 0.544
RB10333
Protein kinase homolog; Best DB hits: BLAST: pir:T42076; protein kinase homolog - Streptomyces coelicolor -----; E=5e-18 pir:T42077; protein kinase homolog - Streptomyces coelicolor -----; E=1e-16 pir:T35491; probable serinethreonine-specific protein kinase pkaF -; E=1e-16 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-15 PFAM: PF00069; Protein kinase domain; E=3.2e-06.
  
   
0.482
pkn2
PMID: 7774814 best DB hits: BLAST: pir:B70936; probable serinethreonine-specific protein kinase (EC; E=3e-31 embl:CAA18685.1; (AL022602) putative serinethreonine protein; E=5e-31 ddbj:BAB06223.1; (AP001515) serinethreonine protein kinase; E=6e-30 COG: Rv2176; COG0515 Serine/threonine protein kinases; E=3e-32 PFAM: PF00069; Protein kinase domain; E=1.2e-49.
  
   
0.467
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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