STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FabGPutative short chain dehydrogenase; PMID: 8290650 best DB hits: BLAST: embl:CAB82049.1; (AL161803) putative short chain dehydrogenase; E=3e-66 pir:B83462; probable short-chain dehydrogenase PA1470 [imported] -; E=4e-58 embl:CAB56135.1; (AL117669) putative short chain oxidoreductase; E=6e-57 COG: PA1470; COG1028 Dehydrogenases with different specificities (related; E=4e-59 BS_fabG; COG1028 Dehydrogenases with different specificities; E=9e-36 DR1943; COG1028 Dehydrogenases with different specificities (related; E=1e-33 PFAM: PF00106; short chain dehydrogenase; E=1.2e-65 PF00678; Short ch [...] (245 aa)    
Predicted Functional Partners:
fabD
Malonyl CoA-acyl carrier protein transacylase; PMID: 1339356 PMID: 7768883 best DB hits: BLAST: embl:CAB45522.1; (AJ007046) [acyl-carrier protein]; E=9e-58 pir:T00580; probable [acyl-carrier-protein] S-malonyltransferase (EC; E=1e-57 gb:AAG43518.1; AF210698_1 (AF210698) malonyl-CoA:ACP transacylase; E=1e-56 COG: HI0156; COG0331 (acyl-carrier-protein) S-malonyltransferase; E=6e-52 PFAM: PF00698; Acyl transferase domain; E=3.2e-16.
 
 0.947
fabG-2
3-oxoacyl-(acyl-carrier protein) reductase; PMID: 10484179 best DB hits: BLAST: ddbj:BAB06210.1; (AP001515) 3-oxoacyl-(acyl-carrier protein); E=1e-17 pir:H75014; 3-oxoacyl-[acyl-carrier-protein] reductase PAB1085 -; E=3e-16 gb:AAK04872.1; AE006311_3 (AE006311) 3-oxoacyl-acyl carrier; E=9e-14 COG: BH2491; COG1028 Dehydrogenases with different specificities (related; E=1e-18 PAB1085; COG1028 Dehydrogenases with different specificities; E=3e-17 DR1943; COG1028 Dehydrogenases with different specificities (related; E=2e-13 PFAM: PF00106; short chain dehydrogenase; E=4.2e-11 PF00678; Short c [...]
  
  
 
0.924
fabG-3
PMID: 8759840 best DB hits: BLAST: pir:H75014; 3-oxoacyl-[acyl-carrier-protein] reductase PAB1085 -; E=6e-34 swissprot:P16543; DHK2_STRVN GRANATICIN POLYKETIDE SYNTHASE; E=9e-33 gb:AAC44307.1; (U59433) 3-ketoacyl-acyl carrier protein reductase; E=2e-30 COG: PAB1085; COG1028 Dehydrogenases with different specificities; E=6e-35 BH2491; COG1028 Dehydrogenases with different specificities (related; E=3e-31 BS_fabG; COG1028 Dehydrogenases with different specificities; E=3e-31 PFAM: PF00106; short chain dehydrogenase; E=1.1e-62.
  
  
 
0.922
fabG
3-oxoacyl-(acyl-carrier protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
 
0.915
RB3657
PMID: 1556094 PMID: 9384377 best DB hits: BLAST: pir:E70027; probable 3-oxoacyl-[acyl-carrier-protein] reductase (EC; E=6e-73 pir:H83476; probable short-chain dehydrogenase PA1344 [imported] -; E=7e-62 embl:CAB60468.1; (AL132856) probable oxidoreductase [Streptomyces; E=8e-54 COG: BS_yvaG; COG1028 Dehydrogenases with different specificities; E=6e-74 PA1344; COG1028 Dehydrogenases with different specificities (related; E=7e-63 BS_yvrD; COG1028 Dehydrogenases with different specificities; E=3e-54 PFAM: PF00106; short chain dehydrogenase; E=1.9e-41 PF00678; Short chain dehydrogenase/reduc [...]
  
  
 
0.910
RB4981
PMID: 8759840 best DB hits: BLAST: pir:E70027; probable 3-oxoacyl-[acyl-carrier-protein] reductase (EC; E=3e-75 pir:H83476; probable short-chain dehydrogenase PA1344 [imported] -; E=2e-60 pir:H70046; probable 3-oxoacyl-[acyl-carrier-protein] reductase (EC; E=1e-53 COG: BS_yvaG; COG1028 Dehydrogenases with different specificities; E=3e-76 PA1344; COG1028 Dehydrogenases with different specificities (related; E=2e-61 BS_yvrD; COG1028 Dehydrogenases with different specificities; E=1e-54 PFAM: PF00106; short chain dehydrogenase; E=5.1e-48 PF00678; Short chain dehydrogenase/reduct; E=3.4e-06 [...]
  
  
 
0.909
fabI
Enoyl-[acyl-carrier-protein] reductase [NADH]; PMID: 8075395 PMID: 8953047 PMID: 10493822 best DB hits: BLAST: gb:AAD04184.1; (L10036) unknown [Nostoc sp. PCC 7120]; E=2e-60 swissprot:Q05069; FABI_ANASP ENOYL-[ACYL-CARRIER-PROTEIN]; E=2e-60 pir:H81284; probable enoyl-[acyl-carrier-protein] reductase [NADH]; E=1e-55 COG: Cj1400c; COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); E=9e-57 BH1511; COG1028 Dehydrogenases with different specificities (related; E=2e-16 BS_yhdF; COG1028 Dehydrogenases with different specificities; E=2e-15 PFAM: PF00106; short chain dehydrogenase; E=0.019 [...]
  
 
0.908
fabI-2
trans-2-enoyl-ACP reductase; PMID: 20138198 best DB hits: BLAST: gb:AAF05840.1; AF197058_1 (AF197058) trans-2-enoyl-ACP reductase; E=6e-31 ddbj:BAB06562.1; (AP001516) enoyl-[acyl-carrier protein]; E=5e-29 gb:AAD04184.1; (L10036) unknown [Nostoc sp. PCC 7120]; E=2e-28 COG: BH2843; COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH); E=5e-30 TM0441; COG1028 Dehydrogenases with different specificities (related; E=1e-09 BS_yfhR; COG1028 Dehydrogenases with different specificities; E=1e-06 PFAM: PF00678; Short chain dehydrogenase/redu; E=7.1e-05.
  
 
 0.908
fabH-2
3-oxoacyl-(acyl-carrier-protein) synthase III; PMID: 1551888 PMID: 10593943 best DB hits: BLAST: pir:C81029; 3-oxoacyl-(acyl-carrier-protein) synthase III NMB1916; E=7e-41 gb:AAK04869.1; AE006310_11 (AE006310); E=1e-39 pir:H82633; beta-ketoacyl-[ACP] synthase III XF1817 [imported] -; E=3e-39 COG: NMB1916; COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III; E=7e-42 PFAM: PF02797; Chalcone and stilbene synthas; E=0.31.
  
 
  0.905
fabH-3
3-oxoacyl-(acyl-carrier protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
  
 
  0.905
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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