STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serBProbable phosphoserine phosphatase; PMID: 2997734 best DB hits: BLAST: pir:C83025; probable phosphoserine phosphatase PA4960 [imported] -; E=1e-108 pir:E70860; probable serB2 protein - Mycobacterium tuberculosis; E=1e-60 pir:T36772; probable phosphoserine phosphatase - Streptomyces; E=1e-57 COG: PA4960_2; COG0560 Phosphoserine phosphatase; E=5e-70 PA4960_1; COG2716 ACT domain-containing protein; E=3e-31 jhp0597; COG0560 Phosphoserine phosphatase; E=6e-26 PFAM: PF01842; ACT domain; E=0.052 PF00702; haloacid dehalogenase-like hy; E=3.6e-26. (485 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase (serine methylase SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.977
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.951
sdaA
L-serine dehydratase; PMID: 2504697 best DB hits: BLAST: pir:B83341; L-serine dehydratase PA2443 [imported] - Pseudomonas; E=1e-141 pir:D82974; L-serine dehydratase PA5379 [imported] - Pseudomonas; E=1e-127 swissprot:O86564; SDHL_STRCO L-SERINE DEHYDRATASE (L-SERINE; E=1e-126 COG: PA2443; COG1760 L-serine deaminase; E=1e-142.
   
 
 0.933
RB8979
Probable L-serine dehydratase, alpha chain; PMID: 2504697 PMID: 8436113 best DB hits: BLAST: swissprot:O34607; SDHA_BACSU PROBABLE L-SERINE DEHYDRATASE, ALPHA; E=1e-26 ddbj:BAB06215.1; (AP001515) L-serine dehydratase alpha subunit; E=9e-26 gb:AAK04929.1; AE006316_10 (AE006316) alpha-subuni L-serine; E=5e-25 COG: BS_ylpA; COG1760 L-serine deaminase; E=1e-27.
   
 
 0.933
trpB
Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.924
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
    
 0.921
pss
Probable CDP-diacylglycerol--serine O-phosphatidyltransferase; PMID: 2830250 best DB hits: BLAST: pir:F71678; CDPdiacylglycerol--serine O-phosphatidyltransferase (EC; E=1e-12 pir:G82804; phosphatidyltransferase XF0442 [imported] - Xylella; E=2e-12 pir:T47268; phosphatidylserine synthase [imported] - Helicobacter; E=3e-12 COG: RP242; COG1183 Phosphatidylserine synthase; E=1e-13 Rv2612c; COG0558 Phosphatidylglycerophosphate synthase; E=1e-05 AF2044; COG1183 Phosphatidylserine synthase; E=1e-05 PFAM: PF01066; CDP-alcohol phosphatidyltrans; E=1.1e-08; Belongs to the CDP-alcohol phosphatidy [...]
    
  0.907
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 
  0.903
RB5098
Serine acetyltransferase, plasmid; PMID: 7603442 best DB hits: BLAST: swissprot:Q59967; SRPH_SYNP7 SERINE ACETYLTRANSFERASE, PLASMID; E=7e-55 ddbj:BAA82868.1; (AB023954) serine acetyltransferase [Entamoeba; E=3e-35 ddbj:BAA82870.1; (AB023956) serine acetyltransferase 2 [Entamoeba; E=8e-34 COG: BH0110; COG1045 Serine acetyltransferase; E=3e-30 BS_ykuQ; COG2171 Tetrahydrodipicolinate N-succinyltransferase; E=2e-04 wcaB; COG1045 Serine acetyltransferase; E=0.002 PFAM: PF00132; Bacterial transferase hexapeptide (f; E=0.078.
    
 0.871
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.840
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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