STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobTProbable nicotinic acid mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. (239 aa)    
Predicted Functional Partners:
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.943
nadD
Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.932
nadK
Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.922
sthA
PMID: 9922271 best DB hits: BLAST: swissprot:P27306; STHA_ECOLI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-154 swissprot:Q9XBQ9; STHA_AZOVI SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-149 swissprot:P50529; STHA_VIBCH SOLUBLE PYRIDINE NUCLEOTIDE; E=1e-146 COG: VC0151; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-147 PFAM: PF00070; Pyridine nucleotide-disulphide; E=6.5e-63 PF02852; Pyridine nucleotide-disulphide; E=1.6e-34.
    
 0.908
pnp
Purine nucleoside phosphorylase I; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.906
punA
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.906
RB12291
Probable NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: pir:G70618; probable pntAB protein - Mycobacterium tuberculosis; E=1e-09 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=2e-08 prf:2102322B; energy-transducing nicotinamide nucleotide; E=7e-07 COG: Rv0156; COG3288 NAD/NADP transhydrogenase alpha subunit; E=1e-10.
     
 0.905
pntA
NAD(P) transhydrogenase subunit alpha; PMID: 3525165 PMID: 1633824 best DB hits: BLAST: prf:2102322A; energy-transducing nicotinamide nucleotide; E=8e-76 pir:S77433; NAD(P)+ transhydrogenase (B-specific) (EC 1.6.1.1) alpha; E=9e-74 gb:AAK00588.1; (AY026033) pyridine nucleotide transhydrogenase; E=1e-72 COG: slr1239; COG3288 NAD/NADP transhydrogenase alpha subunit; E=9e-75 BH2329; COG0686 Alanine dehydrogenase; E=4e-26 PFAM: PF01266; D-amino acid oxidase; E=0.05 PF00070; Pyridine nucleotide-disulphide oxid; E=0.00011 PF01262; Alanine dehydrogenase/pyridine nucl; E=5.4e-89.
     
 0.905
iunH
Inosine-uridine preferring nucleoside hydrolase; PMID: 8634238 best DB hits: BLAST: pdb:1EZR; A Chain A, Crystal Structure Of Nucleoside Hydrolase; E=3e-32 swissprot:Q27546; IUNH_CRIFA INOSINE-URIDINE PREFERRING NUCLEOSIDE; E=2e-31 pdb:2MAS; A Chain A, Purine Nucleoside Hydrolase With A Transition; E=4e-31 COG: yeiK; COG1957 Inosine-uridine nucleoside N-ribohydrolase; E=3e-31 PFAM: PF01156; Inosine-uridine preferring nucle; E=1.9e-51.
   
 
 0.901
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.900
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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