STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
homHomoserine dehydrogenase; PMID: 1333566 best DB hits: BLAST: pir:F69031; homoserine dehydrogenase (EC 1.1.1.3) - Methanobacterium; E=4e-81 gb:AAF21129.1; L78665_3 (L78665) homoserine dehydrogenase; E=2e-80 swissprot:P29365; DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH); E=1e-77 COG: MTH1232; COG0460 Homoserine dehydrogenase; E=4e-82 PFAM: PF02737; 3-hydroxyacyl-CoA dehydrogenase; E=0.85 PF02254; KTN NAD-binding domain; E=0.19 PF01408; Oxidoreductase family, NAD-bind; E=0.73. (448 aa)    
Predicted Functional Partners:
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 0.971
metX
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; In the C-terminal section; belongs to the MetW family.
 
 
 0.954
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.936
thrC
Threonine synthase precursor; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.924
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.923
ectB
Diaminobutyric acid aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.922
RB8221
O-acetylhomoserine sulfhydrylase; PMID: 7704274 best DB hits: BLAST: ddbj:BAB06322.1; (AP001516) O-acetylhomoserine sulfhydrylase; E=1e-123 pir:D72324; O-acetylhomoserine sulfhydrylase - Thermotoga maritima; E=1e-114 pir:T40463; O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) -; E=1e-110 COG: BH2603; COG2873 O-acetylhomoserine sulfhydrylase; E=1e-124 DR0921; COG0626 Cystathionine beta-lyases/cystathionine; E=7e-63 PFAM: PF01053; Cys/Met metabolism PLP-depend; E=6.3e-204.
 
 
 0.883
ilvN
Probable acetolactate synthase small subunit; PMID: 6308579 PMID: 1851954 best DB hits: BLAST: swissprot:O27492; ILVH_METTH PROBABLE ACETOLACTATE SYNTHASE SMALL; E=1e-27 pir:S74358; acetolactate synthase ilvN - Synechocystis sp. (strain; E=5e-27 gb:AAB89532.1; (AE000985) acetolactate synthase, small subunit; E=9e-27 COG: MTH1443; COG0440 Acetolactate synthase, small subunit; E=9e-29 PFAM: PF01842; ACT domain; E=1.1e-18.
  
  
 0.883
ask
Probable aspartokinase; PMID: 7910936 best DB hits: BLAST: pir:S76764; hypothetical protein - Synechocystis sp. (strain PCC; E=2e-96 pir:T35383; probable aspartokinase - Streptomyces coelicolor -----; E=4e-92 swissprot:P41403; AK_MYCSM ASPARTOKINASE (ASPARTATE KINASE); E=7e-90 COG: slr0657; COG0527 Aspartokinases; E=2e-97 PFAM: PF00696; Amino acid kinase family; E=4.9e-68 PF01842; ACT domain; E=6.2e-08.
 
 0.875
ilvE
PMID: 3897211 best DB hits: BLAST: swissprot:Q58414; ILVE_METJA PUTATIVE BRANCHED-CHAIN AMINO ACID; E=3e-07 gb:AAB90305.1; (AE001039) branched-chain amino acid; E=2e-05 pir:F69057; branched-chain amino-acid aminotransferase -; E=6e-05 COG: MJ1008; COG0115 Branched-chain amino acid; E=3e-08.
  
 
 0.871
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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