STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB8547Putative peptidase; Best DB hits: BLAST: pir:F65012; hypothetical protein b2385 - Escherichia coli (strain; E=1e-55 gb:AAG57511.1; AE005469_11 (AE005469) putative peptidase; E=1e-53 pir:D75419; proline dipeptidase - Deinococcus radiodurans (strain; E=1e-49 COG: ypdF; COG0006 Xaa-Pro aminopeptidase; E=1e-56 PFAM: PF00557; metallopeptidase family M24; E=2.9e-50. (368 aa)    
Predicted Functional Partners:
accC
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.664
RB8284
Conserved hypothetical protein-putative a phopsphoesterase or an exonuclease; PMID: 98196666 best DB hits: BLAST: pir:F70440; conserved hypothetical protein aq_1630 - Aquifex; E=3e-18 pir:D71323; conserved hypothetical protein TP0436 - syphilis; E=3e-18 pir:F69999; conserved hypothetical protein ytqI - Bacillus subtilis; E=1e-16 COG: aq_1630; COG0618 Exopolyphosphatase-related proteins; E=3e-19 PFAM: PF01368; DHH family; E=2.4e-12 PF02272; DHHA1 domain; E=2.2e-06.
 
     0.663
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
   
 0.653
accB
acetyl-CoA carboxylase (biotin carboxyl carrier subunit) accB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
       0.642
RB8546
Hypothetical protein.
       0.572
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
 
   
 0.510
pyrH-2
Uridylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
   0.491
korA
2-oxoglutarate ferredoxin oxidoreductase alpha subunit; PMID: 11401501 best DB hits: BLAST: embl:CAC08296.1; (AL392148) putative oxidoreductase [Streptomyces; E=1e-165 embl:CAB60189.1; (AL132824) putative oxidoreductase alpha-subunit; E=1e-164 pir:F70864; probable oxidoreductase alpha subunit - Mycobacterium; E=1e-160 COG: Rv2455c_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=1e-106 Rv2455c_1; COG1014 Pyruvate:ferredoxin oxidoreductase and related; E=2e-46 BH2374_2; COG0674 Pyruvate:ferredoxin oxidoreductase and related; E=2e-40 PFAM: PF01855; Pyruvate flavodoxin/ferredo [...]
     
 0.452
hpnA
HpnA protein; Best DB hits: BLAST: embl:CAA04730.1; (AJ001401) HpnA protein [Zymomonas mobilis]; E=3e-17 swissprot:P73212; DFRA_SYNY3 PUTATIVE DIHYDROFLAVONOL-4-REDUCTASE; E=1e-13 pir:C83067; hypothetical protein PA4631 [imported] - Pseudomonas; E=3e-12 COG: slr1706; COG0451 Nucleoside-diphosphate-sugar epimerases; E=1e-14 PFAM: PF01370; NAD dependent epimerase/dehydra; E=0.51 PF01073; 3-beta hydroxysteroid dehydroge; E=1.6e-06.
  
    0.446
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.423
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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