STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ptsIPhosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (606 aa)    
Predicted Functional Partners:
ptsH
Phosphocarrier protein HPr; PMID: 9172326 best DB hits: BLAST: swissprot:O83598; PTHP_TREPA PHOSPHOCARRIER PROTEIN HPR; E=8e-11 pir:D69607; catabolite repression protein crh [validated] -; E=1e-09 embl:CAB10076.1; (Z97203) histidine containing protein; E=2e-09 COG: TP0589; COG1925 Phosphotransferase system, HPr-related proteins; E=9e-12 PFAM: PF00381; PTS HPr component phosphorylation si; E=5.8e-25.
 
 0.999
RB2992
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
  
  
 
0.922
fruA
Best DB hits: BLAST: ddbj:BAB04547.1; (AP001510) PTS system, fructose-specific enzyme; E=6e-19 gb:AAK05057.1; AE006330_5 (AE006330) fructose-specific PTS system; E=9e-18 ddbj:BAB03332.1; (AB035450) fructose specific permease; E=1e-16 COG: BH0828_1; COG1762 Phosphotransferase system; E=3e-19 TP0085; COG1762 Phosphotransferase system mannitol/fructose-specific; E=5e-16 NMB0736; COG1762 Phosphotransferase system; E=7e-14 PFAM: PF00359; Phosphoenolpyruvate-dependent suga; E=3.6e-13.
 
   
 0.881
RB8592
Best DB hits: BLAST: pir:S77440; hypothetical protein sll1084 - Synechocystis sp. (strain; E=2e-14 embl:CAB75381.1; (AL139298) hypothetical protein SCC88.11c; E=6e-09 pir:E72374; hypothetical protein - Thermotoga maritima (strain; E=4e-05 COG: sll1084; COG1032 Fe-S oxidoreductases family 2; E=2e-15 PFAM: PF02474; Nodulation protein A (NodA); E=0.78.
       0.790
RB8590
Hypothetical protein.
       0.773
trxB
Putative thioredoxin reductase; PMID: 8843436 best DB hits: BLAST: embl:CAB93736.1; (AL357613) putative thioredoxin reductase; E=2e-67 pir:H72322; thioredoxin reductase - Thermotoga maritima (strain; E=2e-27 ddbj:BAB07290.1; (AP001519) thioredoxin reductase (NADPH); E=1e-26 COG: TM0869; COG0492 Thioredoxin reductase/alkyl hydroperoxide reductase; E=2e-28 VNG1259G; COG0492 Thioredoxin reductase/alkyl hydroperoxide; E=1e-21 aq_500; COG0492 Thioredoxin reductase/alkyl hydroperoxide reductase; E=1e-20 PFAM: PF00027; Cyclic nucleotide-binding domai; E=1.6e-07 PF00732; GMC oxidoreductases; E [...]
  
  
 0.694
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
      
 0.657
rne
Ribonuclease E; PMID: 2011493 PMID: 8415644 PMID: 11328869 best DB hits: BLAST: pir:B82538; ribonuclease E XF2607 [imported] - Xylella fastidiosa; E=1e-100 pir:H83273; ribonuclease E PA2976 [imported] - Pseudomonas; E=7e-97 gb:AAK03075.1; (AE006138) Rne [Pasteurella multocida]; E=2e-95 COG: XF2607; COG1530 Ribonucleases G and E; E=1e-101 PFAM: PF00575; S1 RNA binding domain; E=3.6e-07.
     
 0.582
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
     
 0.578
uvrA-2
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
     
 0.578
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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