STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kdgAAlpha-ketoglutarate dehydrogenase E1; PMID: 2404759 PMID: 2404760 best DB hits: BLAST: gb:AAC23516.1; (AF068740) alpha-ketoglutarate dehydrogenase; E1; E=0.0 swissprot:P20707; ODO1_AZOVI 2-OXOGLUTARATE DEHYDROGENASE E1; E=0.0 pir:G83448; 2-oxoglutarate dehydrogenase (E1 subunit) PA1585; E=0.0 COG: PA1585; COG0567 Pyruvate and 2-oxoglutarate dehydrogenases, E1; E=0.0 BH0776; COG1071 Thiamine pyrophosphate-dependent dehydrogenases, E1; E=3e-05 VNG2218G; COG0022 Thiamine pyrophosphate-dependent dehydrogenases,; E=0.008 PFAM: PF00676; Dehydrogenase E1 component; E=3.8e-40. (969 aa)    
Predicted Functional Partners:
sucB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
aceF
PMID: 6345153 PMID: 6821375 PMID: 2121129 best DB hits: BLAST: pir:C82079; pyruvate dehydrogenase, E2 component, dihydrolipoamide; E=4e-55 pir:H75540; pyruvate dehydrogenase complex, dihydrolipoamide; E=4e-55 gb:AAK02978.1; (AE006128) AceF [Pasteurella multocida]; E=6e-54 COG: VC2413; COG0508 Dihydrolipoamide acyltransferases; E=3e-56 PFAM: PF00364; Biotin-requiring enzyme; E=2.1e-20 PF02817; e3 binding domain; E=8.5e-14 PF00198; 2-oxo acid dehydrogenases acylt; E=8.5e-100.
 0.998
dldH
Dihydrolipoamide dehydrogenase; PMID: 8487301 best DB hits: BLAST: swissprot:P14218; DLDH_PSEFL DIHYDROLIPOAMIDE DEHYDROGENASE (E3; E=1e-108 pdb:1LPF; A Chain A, Dihydrolipoamide Dehydrogenase (E.C.1.8.1.4); E=1e-108 pir:A45796; dihydrolipoamide dehydrogenase (EC 1.8.1.4) -; E=1e-108 COG: PA1587; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-109 PFAM: PF00070; Pyridine nucleotide-disulphide; E=1.5e-94 PF02852; Pyridine nucleotide-disulphide; E=5.8e-55.
 
 0.985
lpd
Dihydrolipoamide dehydrogenase; PMID: 6352260 PMID: 2211531 best DB hits: BLAST: pir:A82753; dihydrolipoamide dehydrogenase XF0868 [imported] -; E=1e-102 swissprot:O50286; DLDH_VIBPA DIHYDROLIPOAMIDE DEHYDROGENASE (E3; E=1e-102 swissprot:P00391; DLDH_ECOLI DIHYDROLIPOAMIDE DEHYDROGENASE (E3; E=1e-101 COG: XF0868_2; COG1249 Dihydrolipoamide dehydrogenase/glutathione; E=1e-103 PFAM: PF02032; Phytoene dehydrogenase related; E=0.00021 PF00070; Pyridine nucleotide-disulphide; E=2.6e-75 PF02852; Pyridine nucleotide-disulphide; E=8.6e-41.
  
 0.974
sucC
succinyl-CoA synthetase (beta subunit); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.970
sucD
Putative succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.965
sdhB
Succinate dehydrogenase subunit B; PMID: 98404057 best DB hits: BLAST: embl:CAA69873.1; (Y08563) succinate dehydrogenase subunit B; E=6e-60 ddbj:BAB06810.1; (AP001517) succinate dehydrogenase iron-sulfur; E=1e-58 swissprot:P08066; DHSB_BACSU SUCCINATE DEHYDROGENASE IRON-SULFUR; E=2e-57 COG: BH3091; COG0479 Succinate dehydrogenase/fumarate reductase Fe-S; E=1e-59.
 
 
 0.930
icd
Isocitrate dehydrogenase; PMID: 4149369 best DB hits: BLAST: swissprot:P16100; IDH_AZOVI ISOCITRATE DEHYDROGENASE [NADP]; E=0.0 pir:B81143; isocitrate dehydrogenase NMB0920 [imported] - Neisseria; E=0.0 pir:B82236; isocitrate dehydrogenase VC1141 [imported] - Vibrio; E=0.0 COG: NMB0920; COG2838 Monomeric isocitrate dehydrogenase; E=0.0; Belongs to the monomeric-type IDH family.
   
 
 0.919
sdhC
Succinate dehydrogenase cytochrome B-558 subunit; PMID: 3086287 PMID: 3027051 PMID: 3036777 best DB hits: BLAST: swissprot:P08064; DHSC_BACSU SUCCINATE DEHYDROGENASE CYTOCHROME; E=2e-23 embl:CAA69871.1; (Y08563) succinate dehydrogenase subunit C; E=6e-20 ddbj:BAB06812.1; (AP001517) succinate dehydrogenase cytochrome; E=1e-19 COG: BS_sdhC; COG2009 Succinate dehydrogenase/fumarate reductase; E=2e-24.
  
  
 0.910
gltA
Citrate synthase; PMID: 2337600 PMID: 6380576 best DB hits: BLAST: gb:AAF04133.1; AF191033_1 (AF191033) citrate synthase; E=1e-152 embl:CAB66275.1; (AL136519) citrate synthase. [Streptomyces; E=1e-149 swissprot:Q10530; CISY_MYCTU CITRATE SYNTHASE 1 ----- pir:; E=1e-145 COG: Rv0896; COG0372 Citrate synthase; E=1e-146 PFAM: PF00285; Citrate synthase; E=1e-208.
  
 
 0.903
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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