STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (438 aa)    
Predicted Functional Partners:
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 
 0.925
lueS
Putative leucyl-tRNA synthetase; PMID: 1317842 best DB hits: BLAST: ddbj:BAB17162.1; (AP002868) putative leucyl-tRNA synthetase; E=0.0 embl:CAB77903.1; (AL161500) putative leucyl tRNA synthetase; E=0.0 gb:AAK04914.1; AE006315_3 (AE006315) leucyl-tRNA synthetase (EC; E=0.0 COG: TP0586; COG0495 Leucyl-tRNA synthetase; E=0.0 PFAM: PF00133; tRNA synthetases class I (I, L; E=1.4e-39; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.816
argS
arginyl-tRNA synthetase; PMID: 2668891 best DB hits: BLAST: pir:G82121; arginyl-tRNA synthetase VC2074 [imported] - Vibrio; E=1e-69 swissprot:Q55486; SYR_SYNY3 ARGINYL-TRNA SYNTHETASE; E=5e-68 embl:CAC01600.1; (AJ269505) putative arginyl-tRNA synthetase; E=4e-66 COG: VC2074; COG0018 Arginyl-tRNA synthetase; E=1e-70 PFAM: PF00750; tRNA synthetases class I (R); E=5.7e-55.
  
  
 0.813
tsf
Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.
 
 
 0.788
ispD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
       0.776
xlnC
Probable endo-1,4-beta-xylanase homolog T27I17; PMID: 8917072 best DB hits: BLAST: pir:T05214; hypothetical protein F17I5.50 - Arabidopsis thaliana; E=1e-14 pir:T00624; endo-1,4-beta-xylanase homolog T27I1.7 - Arabidopsis; E=6e-14 ddbj:BAA88262.1; (AB008015) similar to xylan endohydrolase; E=1e-12.
       0.773
rsmC
Probable ribosomal RNA small subunit methyltransferase C; PMID: 9873033 best DB hits: BLAST: pir:E72640; hypothetical protein APE0557 - Aeropyrum pernix (strain; E=7e-07 embl:CAC22834.1; (AL512963) hypothetical [Sulfolobus; E=5e-06 swissprot:P37872; YBXB_BACSU HYPOTHETICAL 22.5 KDA PROTEIN IN; E=9e-06 COG: APE0557; COG0116 Predicted N6-adenine-specific DNA methylases; E=7e-08 BS_ybxB; COG2813 16S RNA G1207 methylase RsmC; E=9e-07 MTH1918; COG2263 Predicted RNA methylase; E=0.004.
       0.773
titin
Similar to titin; Best DB hits: BLAST: embl:CAA62188.1; (X90568) Protein sequence and annotation; E=0.25 pir:I38344; titin, cardiac muscle [validated] - human; E=0.25.
       0.773
glyS
glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
 
  
 0.771
RB5500
Conserved hypothetical protein; PMID: 9665876 best DB hits: BLAST: swissprot:O83487; Y474_TREPA HYPOTHETICAL PROTEIN TP0474 -----; E=5e-54 swissprot:Q51423; Y964_PSEAE HYPOTHETICAL PROTEIN PA0964 -----; E=2e-53 swissprot:O67517; YF75_AQUAE HYPOTHETICAL PROTEIN AQ_1575 -----; E=5e-53 COG: TP0474; COG0217 Uncharacterized ACR; E=4e-55 PFAM: PF01709; Domain of unknown function DUF28; E=8e-105.
 
   0.769
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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