Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AFE_0014Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)    
Predicted Functional Partners:
AFE_1512
Ferredoxin; Identified by similarity to SP:P46036; match to protein family HMM PF00037; match to protein family HMM TIGR02936.
   
 
 0.909
nuoE
NADH-quinone oxidoreductase, E subunit; Identified by match to protein family HMM PF01257; match to protein family HMM TIGR01958.
   
 
 0.907
AFE_0004
Conserved hypothetical protein; Identified by similarity to GB:AAO90130.1.
 
 
 
 0.871
gltD
Glutamate synthase, small subunit; Identified by similarity to SP:P09832; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01318.
   
 
 0.826
hcp
Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
    
   0.775
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.773
smg
Smg family protein; Belongs to the Smg family.
       0.773
AFE_0017
DNA processing protein DprA, putative; Identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732.
       0.773
AFE_0018
LysM domain protein; Identified by match to protein family HMM PF01476.
       0.773
minC
Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family.
       0.559
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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