Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0101ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005. (230 aa)    
Predicted Functional Partners:
AFE_0654
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
  
 
 0.987
AFE_0102
ABC transporter, permease protein, putative; Identified by match to protein family HMM PF02687.
 
 
 0.962
AFE_0100
Conserved hypothetical protein; Identified by similarity to GB:AAM71795.1; match to protein family HMM PF00529.
 
  
 0.872
AFE_0103
Hypothetical protein; Identified by glimmer; putative.
       0.773
lolC
Lipoprotein releasing system transmembrane protein LolC; Identified by similarity to SP:P75956; match to protein family HMM PF02687; match to protein family HMM TIGR02212.
  
 
 0.758
lolA
Outer membrane lipoprotein carrier protein LolA, putative; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
   
 
 0.691
rpsK
Ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
  
   
 0.646
rpsE
Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
  
   
 0.643
cysS
cysteinyl-tRNA synthetase; Identified by similarity to SP:P21888; match to protein family HMM PF01406; match to protein family HMM PF09190; match to protein family HMM PF09334; match to protein family HMM TIGR00435; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
     0.562
AFE_0104
Hypothetical protein; Identified by glimmer; putative.
       0.542
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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