Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0102ABC transporter, permease protein, putative; Identified by match to protein family HMM PF02687. (378 aa)    
Predicted Functional Partners:
AFE_0101
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
 
 
 0.962
AFE_0100
Conserved hypothetical protein; Identified by similarity to GB:AAM71795.1; match to protein family HMM PF00529.
 
     0.948
AFE_0103
Hypothetical protein; Identified by glimmer; putative.
       0.773
lolD
Lipoprotein releasing system, ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
  
 
 0.702
AFE_0655
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
 
 0.702
AFE_0104
Hypothetical protein; Identified by glimmer; putative.
       0.542
lolA
Outer membrane lipoprotein carrier protein LolA, putative; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
   
 
 0.514
AFE_0799
Conserved hypothetical protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
   
 
 0.514
AFE_2763
Outer membrane lipoprotein LolB, putative; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
    
 
 0.466
AFE_2226
Conserved domain protein; Identified by match to protein family HMM PF01636.
  
     0.411
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.