Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0106Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518. (446 aa)    
Predicted Functional Partners:
AFE_0107
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.996
AFE_2319
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.985
AFE_3274
Transcriptional regulator OmpR, putative; Identified by similarity to SP:P03025; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.985
AFE_2318
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
  
  
 
0.927
AFE_3275
Osmolarity sensor protein EnvZ, putative; Identified by similarity to SP:P02933; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
  
  
 
0.920
pdhC
Pyruvate dehydrogenase complex, E2 and E3 components; Dihydrolipoamide acetyltransferase/dihydrolipoamide dehydrogenase; identified by similarity to PIR:C59237; match to protein family HMM PF00070; match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM PF02852; match to protein family HMM PF07992.
    
 0.895
phoB
DNA-binding response regulator PhoB; Identified by similarity to SP:P45605; match to protein family HMM PF00072; match to protein family HMM PF00486; match to protein family HMM TIGR02154.
 
 
 0.889
phoR
Phosphate regulon sensor protein PhoR; Identified by similarity to SP:P08400; match to protein family HMM PF00512; match to protein family HMM PF02518; match to protein family HMM TIGR02966.
 
 
 
 0.813
AFE_2032
DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
   0.767
AFE_2271
Transcriptional regulator, putative; Identified by match to protein family HMM PF00486.
 
   0.760
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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