Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0115Conserved domain protein; Identified by match to protein family HMM PF03724. (478 aa)    
Predicted Functional Partners:
AFE_0018
LysM domain protein; Identified by match to protein family HMM PF01476.
   
    0.782
wrbA
Trp repressor binding protein; Identified by similarity to SP:P30849; match to protein family HMM PF00258; match to protein family HMM TIGR01755.
   
    0.753
AFE_3223
WrbA family protein; Identified by similarity to SP:P30849; Belongs to the WrbA family.
   
    0.753
AFE_0113
Hypothetical protein; Identified by glimmer; putative.
       0.714
AFE_0114
Lipase/esterase, putative; Identified by similarity to SP:P23872; match to protein family HMM PF07859.
       0.714
AFE_0654
ABC transporter, permease protein; Identified by match to protein family HMM PF02687.
   
   0.560
AFE_0112
Conserved hypothetical protein TIGR00650; Identified by similarity to GB:BAC61454.1; match to protein family HMM PF06041.
       0.550
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
     
 0.447
AFE_3128
Hypothetical protein; Identified by glimmer; putative.
  
    0.418
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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