Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFE_0138LPS heptosyltransferase II; Identified by similarity to GB:AAL23754.1; match to protein family HMM PF01075; match to protein family HMM TIGR02195. (369 aa)    
Predicted Functional Partners:
rfaC
Lipopolysaccharide heptosyltransferase 1; Identified by similarity to SP:P24173; match to protein family HMM PF01075; match to protein family HMM TIGR02193.
 
0.977
kdtA
3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.953
gmhA-2
Phosphoheptose isomerase/cytidylyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. Belongs to the SIS family. GmhA subfamily.
 
   
 0.951
AFE_0232
Identified by match to protein family HMM PF04932.
 
 
 0.930
AFE_2582
Histidinol-phosphate phosphatase domain protein; Identified by similarity to GB:AAO91485.1; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.
   
 0.918
AFE_2677
3-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
    
 0.909
AFE_1406
Kinase, pfkB family; Identified by similarity to GB:AAD49846.1; match to protein family HMM PF00294; match to protein family HMM TIGR02198.
 
   
 0.857
gmhA
Phosphoheptose isomerase; Identified by similarity to SP:Q9AGY7; match to protein family HMM TIGR00441.
 
   
 0.777
rfaD
ADP-L-glycero-D-mannoheptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
 
  
 0.777
AFE_0143
Lipoprotein, putative.
 
     0.755
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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