Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (316 aa)    
Predicted Functional Partners:
speH
S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
 
 0.999
AFE_2526
Hydrolase, carbon-nitrogen family; Identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381.
  
 
 0.930
AFE_0150
Conserved hypothetical protein; Identified by similarity to GB:CAE33855.1.
  
  
  0.928
AFE_2160
Conserved hypothetical protein; Identified by similarity to GB:CAE33855.1.
  
  
  0.916
AFE_1826
Identified by match to protein family HMM PF01979; match to protein family HMM PF07969.
   
  0.907
AFE_0432
Conserved hypothetical protein TIGR00726; Identified by similarity to GB:AAQ59864.1; match to protein family HMM PF02578; match to protein family HMM TIGR00726; Belongs to the multicopper oxidase YfiH/RL5 family.
     
  0.900
AFE_1999
Autoinducer synthesis protein; Identified by similarity to SP:P12747; match to protein family HMM PF00765.
     
  0.900
AFE_2123
MTA/SAH nucleosidase, putative; Identified by similarity to SP:P24247; match to protein family HMM PF01048; match to protein family HMM TIGR03468.
     
  0.900
mtnB
Aldolase, class II; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily.
 
   
 0.713
speA
Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine.
    
 0.696
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.