Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0183Type IV pilus assembly protein; Identified by similarity to SP:P45792; match to protein family HMM PF00437; match to protein family HMM PF05157; match to protein family HMM TIGR02538. (569 aa)    
Predicted Functional Partners:
pilC
Type IV pilus biogenesis protein PilC; Identified by similarity to SP:P45793; match to protein family HMM PF00482.
 
 
 0.976
pilD
Type IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
 
 0.920
AFE_0416
Pilin, putative; Identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532.
 
 
 0.843
AFE_1097
Conjugal transfer protein TraN, putative; Identified by similarity to SP:P24082.
  
 
 0.800
anmK
Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.
       0.786
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.786
AFE_0739
Type IV pilus assembly protein PilM; Identified by similarity to PIR:S77726; match to protein family HMM TIGR01175.
 
 
 
 0.783
AFE_0735
Fimbrial assembly protein PilQ, putative; Identified by similarity to SP:P34750; match to protein family HMM PF00263; match to protein family HMM PF03958; match to protein family HMM PF07660; match to protein family HMM TIGR02515.
 
 
 
 0.776
AFE_0738
Type IV pilus biogenesis protein PilN; Identified by match to protein family HMM PF05137.
  
 
 0.706
AFE_1915
Type IV pilus assembly protein PilZ, putative; Identified by similarity to PIR:B59241; match to protein family HMM PF07238.
    
 
 0.684
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.