Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
AFE_0184Sensor protein PilS, putative; Identified by similarity to SP:P33639; match to protein family HMM PF00512; match to protein family HMM PF02518. (530 aa)    
Predicted Functional Partners:
AFE_0185
Type IV fimbriae expression regulatory protein PilR, putative; Identified by similarity to SP:Q00934; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
 0.991
rpoN
RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.928
pilD
Type IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
       0.771
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
       0.768
ntrX
Nitrogen assimilation regulatory protein NtrX, putative; Identified by similarity to SP:Q04849; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF00165; match to protein family HMM PF02954.
 
 
 0.654
AFE_0027
Sigma-54 dependent transcriptional regulator/response regulator; Identified by similarity to SP:Q06065; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
 
 0.599
AFE_0447
Sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF07728.
 
 
 0.590
AFE_2955
Sigma-54 dependent DNA-binding response regulator, putative; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158.
 
 
 0.545
ntrC
Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 
 
 0.544
hupR
Hydrogenase sigma-54 dependent DNA-binding response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
 
 
 0.534
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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