Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pilDType IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (266 aa)    
Predicted Functional Partners:
AFE_0183
Type IV pilus assembly protein; Identified by similarity to SP:P45792; match to protein family HMM PF00437; match to protein family HMM PF05157; match to protein family HMM TIGR02538.
 
 
 0.920
pilC
Type IV pilus biogenesis protein PilC; Identified by similarity to SP:P45793; match to protein family HMM PF00482.
 
  
 0.914
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
    0.870
pilT-2
Twitching motility protein PilT; Identified by similarity to SP:P24559; match to protein family HMM PF00437; match to protein family HMM TIGR01420.
 
   
 0.859
AFE_0017
DNA processing protein DprA, putative; Identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732.
  
  
 0.858
AFE_1087
Type II/IV secretion system protein; Identified by match to protein family HMM PF00437.
 
 
 0.852
pilT-1
Twitching motility protein PilT; Identified by similarity to GB:AAL37755.1; match to protein family HMM PF00437; match to protein family HMM TIGR01420.
  
   
 0.836
AFE_0970
Type IV pilin, putative; Identified by similarity to GB:AAB48595.1; match to protein family HMM PF07963; match to protein family HMM TIGR02532.
  
  
 0.820
AFE_0185
Type IV fimbriae expression regulatory protein PilR, putative; Identified by similarity to SP:Q00934; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
     
 0.808
AFE_0184
Sensor protein PilS, putative; Identified by similarity to SP:P33639; match to protein family HMM PF00512; match to protein family HMM PF02518.
       0.771
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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