Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
zapDConserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (250 aa)    
Predicted Functional Partners:
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
    0.969
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
    
 
 0.816
smg
Smg family protein; Belongs to the Smg family.
  
     0.729
fbp
Fructose-1-6-bisphosphatase; Identified by match to protein family HMM PF00316.
       0.712
holC
DNA polymerase III, chi subunit; Identified by similarity to SP:P28905; match to protein family HMM PF04364.
  
     0.650
pilD
Type IV pilus prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
  
    0.628
AFE_0549
Conserved hypothetical protein; Identified by similarity to PIR:E82325.
  
     0.598
AFE_2065
CvpA family protein; Identified by similarity to SP:P08550; match to protein family HMM PF02674.
  
     0.531
sspB
Identified by similarity to SP:P25663; match to protein family HMM PF04386.
 
     0.522
AFE_0185
Type IV fimbriae expression regulatory protein PilR, putative; Identified by similarity to SP:Q00934; match to protein family HMM PF00072; match to protein family HMM PF00158; match to protein family HMM PF02954.
       0.504
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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