| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ddlB | ftsI | AFE_0203 | AFE_0212 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | 0.949 |
| ddlB | ftsQ | AFE_0203 | AFE_0202 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. | 0.973 |
| ddlB | ftsW | AFE_0203 | AFE_0207 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsW; Identified by similarity to SP:P16457; match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. | 0.977 |
| ddlB | ftsZ | AFE_0203 | AFE_0200 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.760 |
| ddlB | mraY | AFE_0203 | AFE_0209 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.953 |
| ddlB | murC | AFE_0203 | AFE_0205 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.998 |
| ddlB | murD | AFE_0203 | AFE_0208 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.995 |
| ddlB | murE | AFE_0203 | AFE_0211 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.952 |
| ddlB | murF | AFE_0203 | AFE_0210 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.997 |
| ddlB | murG | AFE_0203 | AFE_0206 | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.986 |
| ftsI | ddlB | AFE_0212 | AFE_0203 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.949 |
| ftsI | ftsQ | AFE_0212 | AFE_0202 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | Cell division protein FtsQ; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily. | 0.968 |
| ftsI | ftsW | AFE_0212 | AFE_0207 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | Cell division protein FtsW; Identified by similarity to SP:P16457; match to protein family HMM PF01098; match to protein family HMM TIGR02614; Belongs to the SEDS family. | 0.992 |
| ftsI | ftsZ | AFE_0212 | AFE_0200 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.657 |
| ftsI | mraY | AFE_0212 | AFE_0209 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.930 |
| ftsI | murC | AFE_0212 | AFE_0205 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.957 |
| ftsI | murD | AFE_0212 | AFE_0208 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.949 |
| ftsI | murE | AFE_0212 | AFE_0211 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.988 |
| ftsI | murF | AFE_0212 | AFE_0210 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.941 |
| ftsI | murG | AFE_0212 | AFE_0206 | Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.939 |
