Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0218Identified by match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (456 aa)    
Predicted Functional Partners:
sspA
Identified by similarity to SP:P05838; match to protein family HMM PF00462; match to protein family HMM PF02798.
   
   0.782
AFE_0220
Identified by match to protein family HMM PF00501.
       0.773
dapB
Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.
  
    0.754
AFE_0222
Hypothetical protein; Identified by glimmer; putative.
       0.572
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.520
ftsI
Peptidoglycan synthetase FtsI; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717.
 
     0.492
AFE_2895
Peptidoglycan synthetase FtsI, putative; Identified by similarity to SP:P04286; match to protein family HMM PF00905; match to protein family HMM PF03717.
 
     0.474
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 
 0.447
AFE_2896
Identified by match to protein family HMM PF04932.
 
     0.428
AFE_0026
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
  
 
   0.423
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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