node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFE_0260 | AFE_0261 | AFE_0260 | AFE_0261 | Conserved hypothetical protein TIGR00251, putative; Identified by similarity to SP:Q8DCB7; match to protein family HMM PF02594; Belongs to the UPF0235 family. | Identified by match to protein family HMM PF02325. | 0.826 |
AFE_0260 | bioB | AFE_0260 | AFE_0259 | Conserved hypothetical protein TIGR00251, putative; Identified by similarity to SP:Q8DCB7; match to protein family HMM PF02594; Belongs to the UPF0235 family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.808 |
AFE_0260 | proC | AFE_0260 | AFE_0262 | Conserved hypothetical protein TIGR00251, putative; Identified by similarity to SP:Q8DCB7; match to protein family HMM PF02594; Belongs to the UPF0235 family. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.752 |
AFE_0261 | AFE_0260 | AFE_0261 | AFE_0260 | Identified by match to protein family HMM PF02325. | Conserved hypothetical protein TIGR00251, putative; Identified by similarity to SP:Q8DCB7; match to protein family HMM PF02594; Belongs to the UPF0235 family. | 0.826 |
AFE_0261 | bioB | AFE_0261 | AFE_0259 | Identified by match to protein family HMM PF02325. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.742 |
AFE_0261 | proC | AFE_0261 | AFE_0262 | Identified by match to protein family HMM PF02325. | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. | 0.843 |
AFE_2543 | bioB | AFE_2543 | AFE_0259 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.900 |
AFE_2543 | bioD-1 | AFE_2543 | AFE_1675 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.900 |
AFE_2543 | bioD-2 | AFE_2543 | AFE_0246 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.900 |
AFE_2543 | birA | AFE_2543 | AFE_0453 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | birA bifunctional protein; Identified by match to protein family HMM PF02237; match to protein family HMM PF03099; match to protein family HMM TIGR00121. | 0.900 |
AFE_3011 | bioA | AFE_3011 | AFE_1924 | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.974 |
AFE_3011 | bioB | AFE_3011 | AFE_0259 | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.762 |
AFE_3011 | bioD-1 | AFE_3011 | AFE_1675 | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.830 |
AFE_3011 | bioD-2 | AFE_3011 | AFE_0246 | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.830 |
AFE_3011 | bioF | AFE_3011 | AFE_0243 | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.919 |
bioA | AFE_3011 | AFE_1924 | AFE_3011 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase, putative; Identified by match to protein family HMM PF00155; match to protein family HMM PF00202. | 0.974 |
bioA | bioB | AFE_1924 | AFE_0259 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.991 |
bioA | bioD-1 | AFE_1924 | AFE_1675 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.998 |
bioA | bioD-2 | AFE_1924 | AFE_0246 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.998 |
bioA | bioF | AFE_1924 | AFE_0243 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by similarity to SP:P53555; match to protein family HMM PF00202; match to protein family HMM TIGR00508; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.994 |