Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sqrSulfide quinone reductase, putative; Identified by similarity to GB:AAF72963.1; match to protein family HMM PF07992. (375 aa)    
Predicted Functional Partners:
AFE_2601
Pyridine nucleotide-disulfide oxidoreductase; Identified by similarity to SP:Q9R112; match to protein family HMM PF07992.
 
 
 0.935
AFE_1792
Sulfide-quinone reductase, putative; Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur; Belongs to the SQRD family.
  
  
 
0.927
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
   
 
 0.906
cysJ
Sulfite reductase (NADPH) flavoprotein, alpha component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
     
  0.900
cysI
Sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
     
 0.900
AFE_2556
Conserved hypothetical protein; Identified by similarity to GB:AAM72097.1.
 
     0.622
AFE_2876
Conserved hypothetical protein; Identified by similarity to GB:AAM72097.1.
 
     0.617
AFE_0268
Conserved domain protein; Identified by similarity to GB:CAD79002.1.
 
     0.570
AFE_0743
Conserved domain protein.
  
     0.563
AFE_2529
Hypothetical protein; Identified by glimmer; putative.
  
     0.534
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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