Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AFE_0276Identified by match to protein family HMM PF02366. (556 aa)    
Predicted Functional Partners:
AFE_0228
Glycosyl transferase, group 2 family protein; Identified by match to protein family HMM PF00535.
 
  
 0.831
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
       0.805
AFE_0275
Thiol:disulfide interchange domain protein; Identified by similarity to SP:P77202.
       0.777
AFE_0274
Disulfide bond formation protein B, putative; Identified by similarity to SP:P30018.
       0.773
AFE_1776
Glycosyl transferase; Identified by similarity to SP:O22007; match to protein family HMM PF00535.
 
  
 0.665
AFE_0278
Identified by match to protein family HMM PF00614.
       0.516
AFE_0280
Conserved hypothetical protein; Identified by match to protein family HMM PF03364.
       0.510
AFE_0792
Glycosyl transferase, group 2; Identified by match to protein family HMM PF00535.
  
  
 0.444
lpxB
Lipid A disaccharide synthase LpxB; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
   
 0.430
Your Current Organism:
Acidithiobacillus ferrooxidans
NCBI taxonomy Id: 243159
Other names: A. ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans ATCC 23270, Acidithiobacillus ferrooxidans str. ATCC 23270
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