| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysE-1 | cysE-2 | AFE_1505 | AFE_0671 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | 0.907 |
| cysE-1 | glyA | AFE_1505 | AFE_0295 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.828 |
| cysE-1 | ilvA | AFE_1505 | AFE_0722 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.807 |
| cysE-1 | pssA | AFE_1505 | AFE_0750 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | CDP-diacylglycerol--serine O-phosphatidyltransferse; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
| cysE-1 | serB | AFE_1505 | AFE_0368 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Phosphoserine phosphatase; Identified by similarity to SP:P06862; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.825 |
| cysE-1 | trpA | AFE_1505 | AFE_2068 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.808 |
| cysE-1 | trpB | AFE_1505 | AFE_2069 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.807 |
| cysE-2 | cysE-1 | AFE_0671 | AFE_1505 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | 0.907 |
| cysE-2 | glyA | AFE_0671 | AFE_0295 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.828 |
| cysE-2 | ilvA | AFE_0671 | AFE_0722 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.807 |
| cysE-2 | pssA | AFE_0671 | AFE_0750 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | CDP-diacylglycerol--serine O-phosphatidyltransferse; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.800 |
| cysE-2 | serB | AFE_0671 | AFE_0368 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Phosphoserine phosphatase; Identified by similarity to SP:P06862; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.825 |
| cysE-2 | trpA | AFE_0671 | AFE_2068 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.808 |
| cysE-2 | trpB | AFE_0671 | AFE_2069 | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.807 |
| glyA | cysE-1 | AFE_0295 | AFE_1505 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | 0.828 |
| glyA | cysE-2 | AFE_0295 | AFE_0671 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine O-acetyltransferase; Identified by similarity to SP:Q06750; match to protein family HMM PF00132; match to protein family HMM TIGR01172. | 0.828 |
| glyA | ilvA | AFE_0295 | AFE_0722 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.930 |
| glyA | metX | AFE_0295 | AFE_0293 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.881 |
| glyA | pssA | AFE_0295 | AFE_0750 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferse; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | serB | AFE_0295 | AFE_0368 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase; Identified by similarity to SP:P06862; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.925 |